4-iodo-α-methylbenzeneacetaldehyde

Base Information

• Chemical Name: 4-iodo-α-methylbenzeneacetaldehyde
• CAS No.: 70991-79-6
• Molecular Formula: C₉H₉IO
• Molecular Weight: 260.074
• Mol file: 70991-79-6.mol

Synonyms:4-iodo-α-methylbenzeneacetaldehyde

Chemical Property of 4-iodo-α-methylbenzeneacetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-iodo-α-methylbenzeneacetaldehyde

There total 13 articles about 4-iodo-α-methylbenzeneacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(4-iodophenyl)-2-methyloxirane → 4-iodo-α-methylbenzeneacetaldehyde (70991-79-6)

Guidance literature:

With C₃₆H₅₄IrNP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); In tetrahydrofuran; at 23 - 100 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c4cc05260a

Reference yield: 83.0%

2-(4-iodophenyl)-2-methyloxirane + silica gel (112926-00-8,7631-86-9) → 4-iodo-α-methylbenzeneacetaldehyde (70991-79-6)

Guidance literature:

In toluene;

Reference yield: 47.0%

para-diiodobenzene (624-38-4,1032416-46-8) + allyl alcohol (107-18-6) → 3,3'-(1,4-phenylene)dipropanal (107399-42-8) + 4,4'-diiodobiphenyl (3001-15-8) + 4-iodo-α-methylbenzeneacetaldehyde (70991-79-6) + 2-[4-(3-oxopropyl)phenyl]propanal + 3-(4-iodophenyl)propionaldehyde (213264-51-8)

Guidance literature:

With dichloro(1,5-cyclooctadiene)palladium(II); sodium acetate; In N,N-dimethyl-formamide; at 85 ℃; for 3h; Reagent/catalyst; Solvent; Time; Inert atmosphere;

DOI:10.1016/j.tet.2017.03.034

upstream raw materials:

carbon monoxide

4-iodostyrene

4-Iodoacetophenone

methyl chloroacetate

Downstream raw materials:

(RS)-2-(4'-iodophenyl)propanoic acid

Refernces

• 1、 Cabré, Albert,Cabezas-Giménez, Juanjo,Sciortino, Giuseppe,Ujaque, Gregori,Verdaguer, Xavier,Lledós, Agustí,Riera, Antoni. "Mild Iridium-Catalysed Isomerization of Epoxides. Computational Insights and Application to the Synthesis of β-Alkyl Amines". . p. 3624 - 3631. Retrieved 2019/07/10.
• 2、 Tarnowicz, Stanis?awa,Alsalahi, Waleed,Mieczyńska, Ewa,Trzeciak, Anna M.. "Heck arylation of allyl alcohol catalyzed by Pd(0) nanoparticles". . p. 5605 - 5612. Retrieved 2017/08/26.