Famprofazone

Base Information

• Chemical Name: Famprofazone
• CAS No.: 22881-35-2
• Molecular Formula: C24H31 N3 O
• Molecular Weight: 377.53
• European Community (EC) Number: 245-284-9
• NSC Number: 759244,602800
• UNII: HN0NCX453C
• DSSTox Substance ID: DTXSID3045435
• Nikkaji Number: J11.474J
• Wikipedia: Famprofazone
• Wikidata: Q5433492
• NCI Thesaurus Code: C65616
• Metabolomics Workbench ID: 49606
• ChEMBL ID: CHEMBL1475693
• Mol file: 22881-35-2.mol

Synonyms:4-isopropyl-2-methyl-3-(N-methyl-N-(alpha-methylphenylethyl)aminomethyl)-1-phenyl-3-pyrazolin-5-one;famprofazone;famprofazone hydrochloride

Chemical Property of Famprofazone

Chemical Property:

• Vapor Pressure: 1.45E-09mmHg at 25°C
• Melting Point: 132-133 °C(Solv: ethanol (64-17-5))
• Boiling Point: 485.1°Cat760mmHg
• PKA: 10.28±0.50(Predicted)
• Flash Point: 184.8°C
• PSA: 30.17000
• Density: 1.083g/cm³
• LogP: 4.36240
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 377.246712621
• Heavy Atom Count: 28
• Complexity: 558

Purity/Quality:

99%, ^*data from raw suppliers

Famprofazone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)C1=C(N(N(C1=O)C2=CC=CC=C2)C)CN(C)C(C)CC3=CC=CC=C3
• Uses: analgesic, antipyretic, CNS stimulant Famprofazone, which is known to metabolize to Methamphetamine (M258795) and Amphetamine (A634248) and is included in the prohibited list of the World Anti-Doping Agency. Controlled substance (stimul ant). Famprofazone, which is known to metabolize to Methamphetamine (M258795) and Amphetamine (A634248) and is included in the prohibited list of the World Anti-Doping Agency. Controlled substance (stimulant).

Technology Process of Famprofazone

There total 2 articles about Famprofazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Famprofazon N-oxide (88913-09-1) → 1-phenyl-2-dimethylaminopropane (4075-96-1,49681-82-5) + Famprofazone (22881-35-2) + 3-Formyl-4-isopropyl-2-methyl-1-phenyl-3-pyrazolin-5-on (83957-93-1) + 4-Isopropyl-2-methyl-3-(N-methyl-aminomethyl)-1-phenyl-3-pyrazolin-5-on (83957-94-2) + 4-Isopropyl-2-methyl-3--1-phenyl-3-pyrazolin-5-on (88913-08-0)

Guidance literature:

With tartaric acid; ferric nitrate; In water; for 24h; Product distribution; Heating; also with 0.1 N HCl; various time;

DOI:10.1002/ardp.19843170120

Reference yield:

Famprofazon N-oxide (88913-09-1) → allylbenzene (300-57-2,57807-91-7) + 1-phenyl-2-dimethylaminopropane (4075-96-1,49681-82-5) + Famprofazone (22881-35-2) + 3-(N-Hydroxy-N-methylaminomethyl)-4-isopropyl-2-methyl-1-phenyl-3-pyrazolin-5-on (88913-10-4) + 3-Formyl-4-isopropyl-2-methyl-1-phenyl-3-pyrazolin-5-on (83957-93-1) + 4-Isopropyl-2-methyl-3-(N-methyl-aminomethyl)-1-phenyl-3-pyrazolin-5-on (83957-94-2)

Guidance literature:

In dichloromethane; for 72h; Product distribution; Ambient temperature; various time, various solvent;

DOI:10.1002/ardp.19843170120

Reference yield:

Famprofazone (22881-35-2) → methamphetamin (7632-10-2) + 5-(hydroxymethyl)-4-isopropyl-1-methyl-2-phenyl-1H-pyrazol-3(2H)-one (83957-89-5) + 2-Methyl-3--1-phenyl-3-pyrazolin-5-on + 3-Formyl-4-isopropyl-2-methyl-1-phenyl-3-pyrazolin-5-on (83957-93-1) + 4-Isopropyl-2-methyl-3-(N-methyl-aminomethyl)-1-phenyl-3-pyrazolin-5-on (83957-94-2) + 4-Isopropyl-2-methyl-3--1-phenyl-3-pyrazolin-5-on (88913-08-0)

Guidance literature:

With hydrogenchloride; for 100h; Product distribution; Heating;

DOI:10.1002/ardp.19823151005

upstream raw materials:

Famprofazon N-oxide

Downstream raw materials:

methamphetamin

5-(hydroxymethyl)-4-isopropyl-1-methyl-2-phenyl-1H-pyrazol-3(2H)-one

3-Formyl-4-isopropyl-2-methyl-1-phenyl-3-pyrazolin-5-on

4-Isopropyl-2-methyl-3-(N-methyl-aminomethyl)-1-phenyl-3-pyrazolin-5-on

Refernces