4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

Base Information

• Chemical Name: 4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
• CAS No.: 73771-11-6
• Molecular Formula: C6H6ClN3O
• Molecular Weight: 171.586
• Hs Code.: 2933399090
• Mol file: 73771-11-6.mol

Synonyms:4-Chloro-2-picolinicacid hydrazide;4-Chloropicolinic acid hydrazide;4-Chloropyridine-2-carboxylicacid hydrazide;NSC 146826;4-chloropyridine-2-carbohydrazide;2-pyridinecarboxylic acid, 4-chloro-, hydrazide;2-Pyridinecarboxylic acid, 4-chloro-, hydrazide (9CI);4-Chloropyridine-2-carbohydrazide;

Chemical Property of 4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

Chemical Property:

• Melting Point: 165-167ºC
• Refractive Index: 1.599
• PKA: 10.50±0.10(Predicted)
• PSA: 68.01000
• Density: 1.404 g/cm³
• LogP: 1.42970
• Storage Temp.: Keep Cold

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloropicolinohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

There total 6 articles about 4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-Amino-4-chloropyridine (19798-80-2) + 4-chloro-pyridine-2-carboxylic acid hydrazide (73771-11-6)

Guidance literature:

Reference yield:

methyl 4-chloropyridine-2-carboxylate hydrochloride (176977-85-8) → 4-chloro-pyridine-2-carboxylic acid hydrazide (73771-11-6)

Guidance literature:

With hydrazine hydrate; In methanol; for 2h;

DOI:10.1080/00397919708004207

Reference yield:

4-Chloro-pyridine-2-carboxylic acid methyl ester (24484-93-3) → 4-chloro-pyridine-2-carboxylic acid hydrazide (73771-11-6)

Guidance literature:

With methanol; hydrazine hydrate;

DOI:10.1021/jo01121a002

upstream raw materials:

4-Chloro-pyridine-2-carboxylic acid methyl ester

methyl 4-chloropyridine-2-carboxylate hydrochloride

2-picolinic acid hydrochloride

4-chloro-pyridine-2-carbonyl chloride

Downstream raw materials:

2-Amino-4-chloropyridine

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Refernces

• 1、 -. "SUBSTITUTED PYRIDINE COMPOUNDS AS CRAC MODULATORS". Page/Page column 46; 47; 48-49. . Retrieved 2013/11/19.
• 2、 -. "NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES". Page/Page column 35. . Retrieved 2010/11/27.