N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium trifluoromethanesulfonate

Base Information

• Chemical Name: N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium trifluoromethanesulfonate
• CAS No.: 1280126-07-9
• Molecular Formula: CF₃O₃S*C₉H₁₃FNOS
• Molecular Weight: 351.343
• Mol file: 1280126-07-9.mol

Synonyms:N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium trifluoromethanesulfonate

Chemical Property of N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium trifluoromethanesulfonate

There total 6 articles about N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

α-fluoromethyl-N-methyl-phenylsulphoximine (118268-17-0) + methyl trifluoromethanesulfonate (333-27-7) → N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium trifluoromethanesulfonate (1280126-07-9)

Guidance literature:

at 20 ℃; for 11h; Neat (no solvent); Inert atmosphere;

DOI:10.1002/anie.201006218

Reference yield:

2-fluoro-methylthiobenzene (60839-94-3) → N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium trifluoromethanesulfonate (1280126-07-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; water / methanol / 0.5 h / 20 °C

2.1: sodium azide; sulfuric acid / chloroform / 0 - 20 °C / Inert atmosphere

3.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: 11 h / 20 °C / Neat (no solvent); Inert atmosphere

With N-Bromosuccinimide; sodium azide; sulfuric acid; water; In methanol; dichloromethane; chloroform;

DOI:10.1002/anie.201006218

Reference yield:

phenylthiomethyl chloride (7205-91-6) → N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium trifluoromethanesulfonate (1280126-07-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium fluoride; 18-crown-6 ether / acetonitrile / 168 h / Reflux

2.1: N-Bromosuccinimide; water / methanol / 0.5 h / 20 °C

3.1: sodium azide; sulfuric acid / chloroform / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

5.1: 11 h / 20 °C / Neat (no solvent); Inert atmosphere

With potassium fluoride; N-Bromosuccinimide; sodium azide; 18-crown-6 ether; sulfuric acid; water; In methanol; dichloromethane; chloroform; acetonitrile;

DOI:10.1002/anie.201006218

upstream raw materials:

(fluoromethyl)(imino)(phenyl)-λ⁶-sulfanone

phenylthiomethyl chloride

methyl-phenyl-thioether

2-fluoro-methylthiobenzene

Downstream raw materials:

N,N-(dimethylamino)-S-phenyl-S-monofluoromethyloxosulfonium hexafluorophosphate

Refernces