2,7-Diaminofluorene

Base Information

• Chemical Name: 2,7-Diaminofluorene
• CAS No.: 525-64-4
• Molecular Formula: C13H12N2
• Molecular Weight: 196.252
• Hs Code.: 2921590090
• European Community (EC) Number: 208-377-5
• NSC Number: 12277
• UNII: U63328L315
• DSSTox Substance ID: DTXSID00200503
• Nikkaji Number: J1.581D
• Wikidata: Q27290737
• ChEMBL ID: CHEMBL81945
• Mol file: 525-64-4.mol

Synonyms:2,7-diaminofluorene;2,7-fluorenediamine;2,7-fluorenediamine monohydrochloride

Chemical Property of 2,7-Diaminofluorene

Chemical Property:

• Melting Point: 160-162 °C(lit.)
• Refractive Index: 1.5014 (estimate)
• Boiling Point: 467.021 °C at 760 mmHg
• PKA: 4.63±0.20(Predicted)
• Flash Point: 283.628 °C
• PSA: 52.04000
• Density: 1.284 g/cm³
• LogP: 3.58460
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Slightly soluble in cold water. Soluble in hot water. Sparingly soluble in ethanol. and acetone. Insoluble in ether.
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 196.100048391
• Heavy Atom Count: 15
• Complexity: 217

Purity/Quality:

98%, ^*data from raw suppliers

DAF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Polycyclic Aromatic Hydrocarbons
• Canonical SMILES: C1C2=C(C=CC(=C2)N)C3=C1C=C(C=C3)N
• Uses: 2,7-Diaminofluorene is used to make polyamide resin composites and polyamide films.

Technology Process of 2,7-Diaminofluorene

There total 17 articles about 2,7-Diaminofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,7-dinitro-9H-fluorene (5405-53-8) → 2,7-fluorenediamine (525-64-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; at 20 ℃; for 6h; under 2844.31 Torr;

DOI:10.1021/jm058190h

Reference yield:

C39H28N2 (1221066-40-5) → 2,7-fluorenediamine (525-64-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200901358

Reference yield:

2-amino-7-nitrofluorene (1214-32-0) → 2,7-fluorenediamine (525-64-4)

Guidance literature:

With hydrogenchloride; tin;

upstream raw materials:

2,7-dinitro-phenanthrene-9,10-dione

2,7-dinitro-9H-fluorene

2-amino-7-nitrofluorene

N,N'-(9H-fluorene-2,7-diyl)diacetamide

Downstream raw materials:

N,N'-bis-(4-methoxy-benzylidene)-fluorene-2,7-diyldiamine

2,7-diaminofluoren-9-one

N,N'-(9H-fluorene-2,7-diyl)diacetamide

N-(7-amino-fluoren-2-yl)-phthalamic acid

Refernces

• 1、 Sugiyama, Yuya,Endo, Natsuki,Ishihara, Kazuki,Kobayashi, Yuki,Hamamoto, Hiromi,Shioiri, Takayuki,Matsugi, Masato. "Development of efficient processes for multi-gram scale and divergent preparation of fluorous-Fmoc reagents". . p. 4958 - 4966. Retrieved 2015.
• 2、 Kim, Byeong Wook,Lee, Hwa,Keum, Gyochang,Kim, B. Moon. "Structure-activity relationship (SAR) studies on the mutagenic properties of 2,7-diaminofluorene and 2,7-diaminocarbazole derivatives". supporting information. . Retrieved 2020/11/27.
• 3、 Mousa, Mai H. A.,Ahmed, Nermin S.,Schwedtmann, Kai,Frakolaki, Efseveia,Vassilaki, Niki,Zoidis, Grigoris,Weigand, Jan J.,Abadi, Ashraf H.. "Design and synthesis of novel symmetric fluorene-2,7-diamine derivatives as potent hepatitis C virus inhibitors". . . Retrieved 2021/04/16.