C₁₇H₁₈FN₃O₂

Base Information Edit

Chemical Name:C₁₇H₁₈FN₃O₂
CAS No.:1369769-04-9
Molecular Formula:C₁₇H₁₈FN₃O₂
Molecular Weight:315.347
Hs Code.:
Mol file:1369769-04-9.mol

C<sub>17</sub>H<sub>18</sub>FN<sub>3</sub>O<sub>2</sub>

Synonyms:C₁₇H₁₈FN₃O₂

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Chemical Property of C₁₇H₁₈FN₃O₂ Edit

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Technology Process of C₁₇H₁₈FN₃O₂

There total 7 articles about C₁₇H₁₈FN₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369769-35-6
(1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropanecarboxylic acid

: 1369769-04-9
C₁₇H₁₈FN₃O₂

Guidance literature:: With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 168h;
DOI:10.1021/jm400772t

Reference yield:

: 528587-70-4
(1S,5R)-2-oxo-1-(3-fluorophenyl)-3-oxabicyclo[3.1.0]hexane

: 1369769-04-9
C₁₇H₁₈FN₃O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C

2.1: lipase acrylic resin from Candida antarctica / 17 h / 20 °C / Enzymatic reaction

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / 15 h / 0 - 20 °C

3.2: 1 h / 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -60 - 20 °C

4.2: 14 h / 20 °C

5.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 168 h / 20 °C

With sodium tetrahydroborate; oxalyl dichloride; di-isopropyl azodicarboxylate; lipase acrylic resin from Candida antarctica; ammonium chloride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: |Mitsunobu Displacement / 4.1: |Swern Oxidation;
DOI:10.1021/jm400772t

Reference yield:

: 1369767-20-3
((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

: 1369769-04-9
C₁₇H₁₈FN₃O₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: lipase acrylic resin from Candida antarctica / 17 h / 20 °C / Enzymatic reaction

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / 15 h / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -60 - 20 °C

3.2: 14 h / 20 °C

4.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 168 h / 20 °C

With oxalyl dichloride; di-isopropyl azodicarboxylate; lipase acrylic resin from Candida antarctica; ammonium chloride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 2.1: |Mitsunobu Displacement / 3.1: |Swern Oxidation;
DOI:10.1021/jm400772t