((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol

Base Information Edit

Chemical Name:((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol
CAS No.:1369767-24-7
Molecular Formula:C₁₇H₁₉FN₂O₂
Molecular Weight:302.348
Hs Code.:
Mol file:1369767-24-7.mol

Synonyms:((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol

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Chemical Property of ((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol Edit

Chemical Property:

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Technology Process of ((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol

There total 11 articles about ((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450904-94-5
C₁₉H₂₁FN₂O₃

: 1369767-24-7
((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol

Guidance literature:: With water; sodium hydroxide; In acetonitrile; at 20 - 25 ℃;

Reference yield:

: 1369767-20-3
((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

: 1369767-24-7
((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: Candida Antarctica Lipase B / 2-methyltetrahydrofuran / 20 - 25 °C / Inert atmosphere; Enzymatic reaction

2: pyridine / 2-methyltetrahydrofuran / 1 h / 10 - 15 °C / Inert atmosphere

3: caesium carbonate / acetonitrile / 65 - 70 °C / Inert atmosphere

4: water; sodium hydroxide / acetonitrile / 20 - 25 °C

With pyridine; water; caesium carbonate; sodium hydroxide; In 2-methyltetrahydrofuran; acetonitrile;

Reference yield:

: 501-00-8
3-fluorophenylacetonitrile

: 1369767-24-7
((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 29 h / -3 - 7 °C

2: potassium hydroxide; water / ethanol / 5 h / 80 °C

3: hydrogenchloride / ethanol; water / 2 h / 60 °C

4: lithium borohydride / tetrahydrofuran; 2-methyltetrahydrofuran / -10 - 25 °C / Inert atmosphere

5: Candida Antarctica Lipase B / 2-methyltetrahydrofuran / 20 - 25 °C / Inert atmosphere; Enzymatic reaction

6: pyridine / 2-methyltetrahydrofuran / 1 h / 10 - 15 °C / Inert atmosphere

7: caesium carbonate / acetonitrile / 65 - 70 °C / Inert atmosphere

8: water; sodium hydroxide / acetonitrile / 20 - 25 °C

With pyridine; hydrogenchloride; lithium borohydride; water; sodium hexamethyldisilazane; caesium carbonate; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water; acetonitrile;