Flutrimazole

Base Information

• Chemical Name: Flutrimazole
• CAS No.: 119006-77-8
• Molecular Formula: C22H16F2N2
• Molecular Weight: 346.379
• Hs Code.: 2933299090
• European Community (EC) Number: 642-917-4
• UNII: 776S0UP252
• DSSTox Substance ID: DTXSID30869622
• Nikkaji Number: J480.098B
• Wikipedia: Flutrimazole
• Wikidata: Q5462984
• NCI Thesaurus Code: C167003
• Metabolomics Workbench ID: 154236
• ChEMBL ID: CHEMBL2107430
• Mol file: 119006-77-8.mol

Synonyms:1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole;Cutimian;Flusporan;flutrimazole;Funcenal;Micetal;UR 4056;UR-4056

Chemical Property of Flutrimazole

Chemical Property:

• Vapor Pressure: 4.16E-08mmHg at 25°C
• Melting Point: 161-166 °C
• Refractive Index: 1.59
• Boiling Point: 457.1 °C at 760 mmHg
• PKA: 6.03±0.34(Predicted)
• Flash Point: 230.3 °C
• PSA: 17.82000
• Density: 1.15 g/cm³
• LogP: 5.00150
• Storage Temp.: -20°C Freezer
• Solubility.: Practically insoluble in water, freely soluble in tetrahydrofuran, soluble in methanol.
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 346.12815484
• Heavy Atom Count: 26
• Complexity: 445

Purity/Quality:

99% ^*data from raw suppliers

Flutrimazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=CC=C3F)N4C=CN=C4
• Description: Flutrimazole, a novel imidazole antifungal launched in Spain, is indicated for mycosis of the skin. Flutrimazole displays potent broad-spectrum of activity against dematophytes, filamentous fungi and yeasts, saprophytic and pathogenic to animals and humans. Similar to other imidazole and triazole antifungals, flutrimazole exerts its biological function through inhibition of fungal lanosterol 14a-demethylase. Excellent local and systemic tolerance of flutrimazole in patients has been reported.
• Uses: Flutrimazole is a new imidazole antifungal agent with anti-inflammatory properties as well. Antifungal

Technology Process of Flutrimazole

There total 5 articles about Flutrimazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ flutrimazole (119006-77-8)

Guidance literature:

Reference yield:

o-fluorobenzophenone (342-24-5) → flutrimazole (119006-77-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h

2: thionyl chloride / 4 h / Heating

3: triethylamine / acetonitrile / 3 h / Heating

With thionyl chloride; magnesium; triethylamine; In acetonitrile;

Reference yield:

(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol (128092-72-8) → flutrimazole (119006-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / Heating

2: triethylamine / acetonitrile / 3 h / Heating

With thionyl chloride; triethylamine; In acetonitrile;

upstream raw materials:

1H-imidazole

(2-fluorophenyl)-(4-fluorophenyl)phenylchloromethane

o-fluorobenzophenone

(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol

Refernces

• 1、 -. "1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole useful as antifungal agent". . . Retrieved 2008/06/13.