Name: 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole
SKU: 119006-77-8

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Basic Information

Molecular Structure:
CAS No.:	119006-77-8
Name:	1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole
Article Data:	3

Formula:	C₂₂H₁₆F₂N₂
Molecular Weight:	346.379
Synonyms:	1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole;UR 4056;
Density:	1.15 g/cm³
Melting Point:	161-166 °C
Boiling Point:	457.1 °C at 760 mmHg
Flash Point:	230.3 °C
PSA:	17.82000
LogP:	5.00150

Synthetic route

: 288-32-4
1H-imidazole

: 128092-75-1
(2-Fluorophenyl)(4-fluorophenyll)phenylchloromethane

: 119006-77-8
flutrimazole

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 3h; Heating; Yield given;

: 342-24-5
o-fluorobenzophenone

: 119006-77-8
flutrimazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h 2: thionyl chloride / 4 h / Heating 3: triethylamine / acetonitrile / 3 h / Heating View Scheme

: 128092-72-8
(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol

: 119006-77-8
flutrimazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride / 4 h / Heating 2: triethylamine / acetonitrile / 3 h / Heating View Scheme

: 460-00-4
1-Bromo-4-fluorobenzene

: 119006-77-8
flutrimazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h 2: thionyl chloride / 4 h / Heating 3: triethylamine / acetonitrile / 3 h / Heating View Scheme

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Chemistry

Molecular Formula: C₂₂H₁₆F₂N₂
Molecular Weight: 346.373 g/mol.
Index of Refraction: 1.59
Density: 1.15 g/cm³
Flash Point: 230.3 °C
Enthalpy of Vaporization: 68.97 kJ/mol
Boiling Point: 457.1 °C at 760 mmHg
Vapour Pressure: 4.16E-08 mmHg at 25 °C
Melting point: 161-166 °C
Structure of Flutrimazole (CAS NO.119006-77-8):

IUPAC Name: 1-[(2-Fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
Product Category of Flutrimazole (CAS NO.119006-77-8): Flutrimazole

Uses

Flutrimazole(CAS NO.119006-77-8) is used for the topical treatment of superficial mycoses of the skin, such as tinea in all its forms: tinea pedis (athlete's foot), tinea cruris, tinea corporis, tinea faciei et barbae and tinea inguinalis, caused by Trichophyton, Microsporum and by Epidermophyton floccosum. It is also indicated for the treatment of pityriasis versicolor caused by Malassezia furfur, also known as Pityrosporum ovale.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.
mouse	LD50	oral	> 1gm/kg (1000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.
rat	LD50	intraperitoneal	1079mg/kg (1079mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.
rat	LD50	oral	808mg/kg (808mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.

Safety Profile

Flutrimazole (CAS NO.119006-77-8) may cause burning, irritation, pruritus and erythema in the treated zone. It shows a very low acute toxicity. Its topical administration does not cause sensitization and has no potential for inducing phototoxicity or photosensitivity.

Specification

Flutrimazole , its cas register number is 119006-77-8. It also can be called 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole ; Micetal ; and Flusporan . It is a wide spectrum antifungal drug, and is practically insoluble in water, freely soluble in tetrahydrofuran and soluble in methanol. It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol-14-demethylase.