4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene

Base Information

• Chemical Name: 4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene
• CAS No.: 1099595-82-0
• Molecular Formula: C₁₄H₉F₃O₂
• Molecular Weight: 266.219
• Mol file: 1099595-82-0.mol

Synonyms:4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene

Chemical Property of 4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene

There total 5 articles about 4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(benzo[d][1,3]dioxol-5-yl)-5,5-dimethyl-1,3,2-dioxaborinane + p-trifluoromethylphenyl bromide (402-43-7) → 4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene (1099595-82-0)

Guidance literature:

With P(t-Bu)3 Palladacycle Gen_. 3; potassium trimethylsilonate; In tetrahydrofuran; at 23 ℃; for 0.0833333h;

DOI:10.1021/acscatal.9b04353

Reference yield: 94.0%

5-chloro-1,3-benzodioxole (7228-38-8) + C9H10F3OS(1-)*Na(1+) → 4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene (1099595-82-0)

Guidance literature:

With η³-1-tert-butylindenyl palladium chloride dimer; In toluene; at 70 ℃; for 4h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/acs.orglett.6b02330

Reference yield: 91.0%

benzo[d][1,3]dioxol-5-yl methanesulfonate (128612-45-3) + 4-trifluoromethylphenyltriethoxysilane (188748-63-2) → 4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene (1099595-82-0)

Guidance literature:

With 2-[2-(dicyclohexylphosphino)-phenyl]-1-methyl-1H-indole; tetrabutyl ammonium fluoride; palladium diacetate; acetic acid; In tert-butyl alcohol; at 90 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol802493z

upstream raw materials:

benzo[d][1,3]dioxol-5-yl methanesulfonate

4-trifluoromethylphenyltriethoxysilane

p-trifluoromethylphenyl bromide

1,2-(methylenedioxy)-4-bromobenzene

Refernces

• 1、 Melvin, Patrick R.,Hazari, Nilay,Beromi, Megan Mohadjer,Shah, Hemali P.,Williams, Michael J.. "Pd-Catalyzed Suzuki-Miyaura and Hiyama-Denmark Couplings of Aryl Sulfamates". supporting information. p. 5784 - 5787. Retrieved 2016/11/29.
• 2、 Chu, Wenyi,Li, Xinmin,Hou, Yanjun,Wang, Hua,Li, Hongyu,Yuan, Xiaobin,Sun, Zhizhong. "18-Crown-6 promoting Pd/C-catalyzed cross-coupling reaction of aryl bromides and arylboronic acids in aqueous media". . p. 478 - 482. Retrieved 2012/10/29.