1,3-benzodioxol-5-yl methanesulfonate

Base Information

• Chemical Name: 1,3-benzodioxol-5-yl methanesulfonate
• CAS No.: 128612-45-3
• Molecular Formula: C₈H₈O₅S
• Molecular Weight: 216.215
• Mol file: 128612-45-3.mol

Synonyms:benzo[d][1,3]dioxol-5-yl methanesulfonate

Chemical Property of 1,3-benzodioxol-5-yl methanesulfonate

Chemical Property:

• Boiling Point: 364.6±42.0 °C(Predicted)
• Density: 1.484±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-benzodioxol-5-yl methanesulfonate

There total 2 articles about 1,3-benzodioxol-5-yl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Sesamol (533-31-3) + methanesulfonyl chloride (124-63-0) → benzo[d][1,3]dioxol-5-yl methanesulfonate (128612-45-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1055/s-0034-1379483

Reference yield:

Sesamol (533-31-3) + Methanesulfonic anhydride (7143-01-3) → benzo[d][1,3]dioxol-5-yl methanesulfonate (128612-45-3)

Guidance literature:

With 2,4,6-trimethyl-pyridine; In toluene; at 120 ℃; for 3h;

DOI:10.1021/cs500587b

Reference yield: 97.0%

benzoxazole (273-53-0,29791-96-6) + benzo[d][1,3]dioxol-5-yl methanesulfonate (128612-45-3) → 2-(3',4'-Methylendioxyphenyl)benzoxazol (3315-20-6)

Guidance literature:

With palladium diacetate; caesium carbonate; cesium pivalate; 1,2-bis-(dicyclohexylphosphino)ethane; In toluene; at 120 ℃;

DOI:10.1021/cs500587b

upstream raw materials:

Sesamol

methanesulfonyl chloride

Methanesulfonic anhydride

Downstream raw materials:

(1S,3S)-1-[3,4-(methylenedioxy)phenoxy]-8-N-methyl-3-p-tolyl-8-aza-bicyclo[3.2.2]nonane

3,4-methylenedioxybiphenyl

4-trifluoromethyl-1-(3,4-methylenedioxyphenyl)lbenzene

N-(benzo[d][1,3]dioxol-5-yl)-2-methylbenzamide

Refernces

• 1、 Ferguson, Devin M.,Rudolph, Stacey R.,Kalyani, Dipannita. "Palladium-catalyzed intra-and intermolecular C-H arylation using mesylates: Synthetic scope and mechanistic studies". . p. 2395 - 2401. Retrieved 2014/07/21.
• 2、 Chow, Wing Kin,So, Chau Ming,Lau, Chak Po,Kwong, Fuk Yee. "Palladium-catalyzed borylation of aryl mesylates and tosylates and their applications in one-pot sequential suzuki-miyaura biaryl synthesis". supporting information; experimental part. p. 6913 - 6917. Retrieved 2011/08/03.