4-(2,5-diphenyl-1H-pyrrol-1-yl)phenol

Base Information

• Chemical Name: 4-(2,5-diphenyl-1H-pyrrol-1-yl)phenol
• CAS No.: 853-38-3
• Molecular Formula: C₂₂H₁₇NO
• Molecular Weight: 311.383
• Mol file: 853-38-3.mol

Synonyms:1-(4-hydroxyphenyl)-2,5-diphenyl-1H-pyrrole

Chemical Property of 4-(2,5-diphenyl-1H-pyrrol-1-yl)phenol

Chemical Property:

• Boiling Point: 523.9±38.0 °C(Predicted)
• PKA: 8.72±0.30(Predicted)
• Density: 1.10±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2,5-diphenyl-1H-pyrrol-1-yl)phenol

There total 6 articles about 4-(2,5-diphenyl-1H-pyrrol-1-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-amino-phenol (123-30-8) + phenacylacetophenone (495-71-6) → 1-(4-hydroxyphenyl)-2,5-diphenyl-1H-pyrrole (853-38-3)

Guidance literature:

With trifluoroacetic acid; In toluene; at 110 ℃; for 3h;

DOI:10.1055/a-1482-2567

Reference yield:

chloro-trimethyl-silane (75-77-4) + 1-(4-methoxyphenyl)-2,5-diphenyl-1H-pyrrole (855-31-2) → 1-(4-hydroxyphenyl)-2,5-diphenyl-1H-pyrrole (853-38-3) + 4-trimethylsilylanisole (877-68-9) + 4-(trimethylsilyl)phenol (13132-25-7)

Guidance literature:

1-(4-methoxyphenyl)-2,5-diphenyl-1H-pyrrole; With lithium; In tetrahydrofuran; at 0 ℃; for 4h; Schlenk technique; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; at 0 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1055/a-1482-2567

Reference yield:

phenacylacetophenone (495-71-6) → 1-(4-hydroxyphenyl)-2,5-diphenyl-1H-pyrrole (853-38-3)

Guidance literature:

Multi-step reaction with 2 steps

2: pyridine hydrochloride

With pyridine hydrochloride;

upstream raw materials:

1-(4-methoxyphenyl)-2,5-diphenyl-1H-pyrrole

4-amino-phenol

phenacylacetophenone

4-methoxy-aniline

Downstream raw materials:

4-(trimethylsilyl)phenol

Refernces