Technology Process of 6-Chloro-7,8-dimethoxy-1-(4-methoxy-phenyl)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carbaldehyde
There total 15 articles about 6-Chloro-7,8-dimethoxy-1-(4-methoxy-phenyl)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
2: 19 percent / 2.5 h / Heating
3: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C
4: 24 h / 25 °C
With
sulfuric acid; borane; trifluoroacetic acid;
In
tetrahydrofuran;
DOI:10.1021/jm00161a029
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 90 percent / Cl2
2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
4: 97 percent / 12N aq. HCl
5: 96 percent / dimethylsulfoxide / 1.25 h
6: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
7: 19 percent / 2.5 h / Heating
8: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C
9: 24 h / 25 °C
With
hydrogenchloride; sodium tetrahydroborate; sulfuric acid; borane; chlorine; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00161a029
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
2: 97 percent / 12N aq. HCl
3: 96 percent / dimethylsulfoxide / 1.25 h
4: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
5: 19 percent / 2.5 h / Heating
6: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C
7: 24 h / 25 °C
With
hydrogenchloride; sodium tetrahydroborate; sulfuric acid; borane; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00161a029