Technology Process of 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-methyl-1H-3-benzazepine-7,8-diol
There total 16 articles about 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-methyl-1H-3-benzazepine-7,8-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
borane;
In
tetrahydrofuran;
for 2.5h;
Yield given;
Ambient temperature;
DOI:10.1021/jm00155a024
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 90 percent / Cl2
2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
4: 97 percent / 12N aq. HCl
5: 96 percent / dimethylsulfoxide / 1.25 h
6: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
7: 19 percent / 2.5 h / Heating
8: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C
9: 24 h / 25 °C
10: BH3 / tetrahydrofuran / 16 h / 25 °C
With
hydrogenchloride; sodium tetrahydroborate; sulfuric acid; borane; chlorine; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00161a029
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
2: 19 percent / 2.5 h / Heating
3: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C
4: 24 h / 25 °C
5: BH3 / tetrahydrofuran / 16 h / 25 °C
With
sulfuric acid; borane; trifluoroacetic acid;
In
tetrahydrofuran;
DOI:10.1021/jm00161a029