Hexafluoroglutaric acid

Base Information

• Chemical Name: Hexafluoroglutaric acid
• CAS No.: 376-73-8
• Molecular Formula: C5H2F6O4
• Molecular Weight: 240.059
• Hs Code.: 29171900
• European Community (EC) Number: 206-813-9
• NSC Number: 6826
• UNII: AI43ZAB49W
• DSSTox Substance ID: DTXSID8059926
• Nikkaji Number: J208.602F
• Wikidata: Q81985264
• Mol file: 376-73-8.mol

Synonyms:Hexafluoroglutaric acid;376-73-8;Perfluoroglutaric acid;Hexafluoropentanedioic Acid;Pentanedioic acid, hexafluoro-;2,2,3,3,4,4-Hexafluoropentanedioic acid;Glutaric acid, hexafluoro-;HEXAFLUOROGLUTARICACID;C5H2F6O4;Perfluoropentanedioic acid;AI43ZAB49W;Pentanedioic acid, 2,2,3,3,4,4-hexafluoro-;NSC 6826;NSC-6826;EINECS 206-813-9;UNII-AI43ZAB49W;Perfluoroglutaric acid, 97%;SCHEMBL430675;DTXSID8059926;NSC6826;C5-H2-F6-O4;MFCD00004172;AKOS000119366;2,2,3,3,4,4-hexafluoropentanedioate;AT23287;FS-3843;2,2,3,3,4,4-hexafluoroglutaric acid;FT-0626995;H0658;2,2,3,3,4,4-Hexafluoropentanedioic acid #;EN300-20459;A823822

Chemical Property of Hexafluoroglutaric acid

Chemical Property:

• Appearance/Colour: almost white to light beige adhering cryst. powder
• Vapor Pressure: 0.000548mmHg at 25°C
• Melting Point: 88-91 °C(lit.)
• Boiling Point: 289.6 °C at 760 mmHg
• PKA: 0.23±0.10(Predicted)
• Flash Point: 104.6 °C
• PSA: 74.60000
• Density: 1.802 g/cm³
• LogP: 1.06150
• Sensitive.: Hygroscopic
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 4
• Exact Mass: 239.98572751
• Heavy Atom Count: 15
• Complexity: 270

Purity/Quality:

98% ^*data from raw suppliers

Hexafluoroglutaric Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 34-37
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Organic Acids
• Canonical SMILES: C(=O)(C(C(C(C(=O)O)(F)F)(F)F)(F)F)O

Technology Process of Hexafluoroglutaric acid

There total 36 articles about Hexafluoroglutaric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,2-dichloro-3,3,4,4,5,5-hexafluorocyclopentene (706-79-6) → hexafluoroglutaric acid (376-73-8)

Guidance literature:

With potassium permanganate; at 5 ℃; for 6h; Reagent/catalyst;

Reference yield: 90.5%

hexafluoropentanedioyl dichloride (678-77-3) + hexafluoroglutaric anhydride (376-68-1) → hexafluoroglutaric acid (376-73-8)

Guidance literature:

With water; at 40 ℃; for 2h;

Reference yield: 90.0%

octaperfluorocyclopentene (559-40-0) → hexafluoroglutaric acid (376-73-8)

Guidance literature:

With ruthenium(III) trichloride hydrate; periodic acid; In tetrachloromethane; water; acetonitrile; at 0 - 23 ℃; for 12h; Reagent/catalyst; Solvent; Temperature;

upstream raw materials:

3H-nonafluoro-cyclohexene

1,3,3,4,4,5,5-heptafluoro-2-methoxy-cyclopentene

hexafluoropentanedioyl dichloride

1-Bromheptafluor-1-cyclopenten

Downstream raw materials:

diethyl perfluoroglutarate

hexafluoro-dihydro-furan-2-one

hexafluoroglutaric anhydride

bis<2-(4-aminophenyl)hexafluoro-propyl> hexafluoroglutarate

Refernces

• 1、 -. "Preparation method of fluorine-containing carboxylic acid". Paragraph 0056-0060. . Retrieved 2020/07/12.
• 2、 -. "Production process of fluorine-containing carboxylic acid". Paragraph 0032-0034. . Retrieved 2020/07/13.