Azaniumylmethyl(hydroxy)phosphinate

Base Information

• Chemical Name: Azaniumylmethyl(hydroxy)phosphinate
• CAS No.: 1066-51-9
• Molecular Formula: CH6NO3P
• Molecular Weight: 111.037
• Hs Code.: 29319090
• Mol file: 1066-51-9.mol

Synonyms:CHEMBL41873;BDBM50024591

Chemical Property of Azaniumylmethyl(hydroxy)phosphinate

Chemical Property:

• Appearance/Colour: white crystals or powder
• Vapor Pressure: 4.29E-06mmHg at 25°C
• Melting Point: 300 °C
• Refractive Index: 1.505
• Boiling Point: 358 °C at 760 mmHg
• PKA: pK1: 2.35;pK2: 5.9;pK3: 10.8 (25°C)
• Flash Point: 170.3 °C
• PSA: 93.36000
• Density: 1.635 g/cm³
• LogP: -0.21940
• Storage Temp.: 0-6°C
• Sensitive.: Hygroscopic
• Solubility.: water: soluble50mg/mL, clear, colorless
• Water Solubility.: soluble
• XLogP3: -4.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 111.00853005
• Heavy Atom Count: 6
• Complexity: 72.6

Purity/Quality:

99.9% ^*data from raw suppliers

AminomethanephosphonicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C,T
• Statements: 36/37/38-35-39/23/24/25-20/21/22
• Safety Statements: 26-36-24/25-45-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C([NH3+])P(=O)(O)[O-]
• Uses: Aminomethanephosphonic acid is a degradation product of glyphosate (G765000), a herbicide. (Aminomethyl)phosphonic acid is used in the preparation of (acetylamino-methyl)-phosphonic acid by reacting with acetic anhydride. Further, it is used in the development of immobilized metal affinity chromatography column based on organic-inorganic hybrid silica monolith.

Technology Process of Azaniumylmethyl(hydroxy)phosphinate

There total 52 articles about Azaniumylmethyl(hydroxy)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

O,O-dimethyl-N-phosphonomethylbenzamide → Aminomethylphosphonic acid (1066-51-9) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With hydrogenchloride; for 18h; Heating;

Reference yield: 96.0%

N-acetylaminomethylphosphonic acid (57637-97-5) → Aminomethylphosphonic acid (1066-51-9)

Guidance literature:

With hydrogenchloride; at 70 - 80 ℃; for 1h;

Reference yield: 54.0%

N-(triphenylmethyl)methanimine (120060-75-5) + acetic anhydride (108-24-7) → Aminomethylphosphonic acid (1066-51-9) + nitrilo-tris(methylenephosphonic acid) (6419-19-8,103333-74-0) + (iminobismethylene)bisphosphonic acid (17261-34-6)

Guidance literature:

acetic anhydride; With phosphonic Acid; at 0 - 20 ℃;

N-(triphenylmethyl)methanimine; at 0 ℃;

With hydrogenchloride; water; for 8h; Reflux;

DOI:10.3998/ark.5550190.0011.b29

upstream raw materials:

N-(bromomethyl)phtalimide

triethyl phosphite

aminomethyl-phosphonic acid monoethyl ester

N-(hydroxymethyl)acetamide

Downstream raw materials:

N-t-butoxycarbonylaminomethylphosphonic acid

N-(4-cyanophenyl)-N'-<(disodiophosphono)methyl>urea

guanidinomethanephosphonic acid

N-methyl-acetamide

Refernces

• 1、 Gillet, Rapha?l,Roux, Amandine,Brandel, Jérémy,Huclier-Markai, Sandrine,Camerel, Franck,Jeannin, Olivier,Nonat, Aline M.,Charbonnière, Lo?c J.. "A Bispidol Chelator with a Phosphonate Pendant Arm: Synthesis, Cu(II) Complexation, and 64Cu Labeling". . p. 11738 - 11752. Retrieved 2017.
• 2、 Cypryk, Marek,Drabowicz, Jozef,Gostynski, Bartlomiej,Kudzin, Marcin H.,Kudzin, Zbigniew H.,Urbaniak, Pawel. "1-(N-Acylamino)alkylphosphonic acids—Deacylation in aqueous solutions". . p. 651 - 658. Retrieved 2017.
• 3、 Pinel, Catherine,Landrivon, Emmanuel,Lini, Hedi,Gallezot, Pierre. "Effect of the nature of carbon catalysts on glyphosate synthesis". . p. 515 - 519. Retrieved 1999.
• 4、 Riley, Dennis P.,Fields, Donald L.,Rivers, Willie. "Homogeneous catalysts for selective molecular oxygen driven oxidative decarboxylations". . p. 3371 - 3378. Retrieved 1991.
• 5、 -. "PROCESS FOR OXIDATION OF N-(PHOSPHONOMETHYL)IMINODIACETIC ACID". Paragraph 0104. . Retrieved 2015/11/10.