4-Aminophenyldichloroarsine

Base Information

• Chemical Name: 4-Aminophenyldichloroarsine
• CAS No.: 5410-78-6
• Molecular Formula: C6H6 As Cl2 N . Cl H
• Molecular Weight: 274.409
• Hs Code.: 2931900090
• Mol file: 5410-78-6.mol

Synonyms:4-aminophenyldichloroarsine;4-dichloroarsinoaniline;p-aminophenyldichloroarsine

Chemical Property of 4-Aminophenyldichloroarsine

Chemical Property:

• Vapor Pressure: 0.000173mmHg at 25°C
• Boiling Point: 329.8°Cat760mmHg
• Flash Point: 153.3°C
• PSA: 26.02000
• Density: g/cm³
• LogP: 2.02280
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 272.886002
• Heavy Atom Count: 11
• Complexity: 102

Purity/Quality:

99%, ^*data from raw suppliers

p-AminophenyldichloroarsineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1[NH3+])[As](Cl)Cl.[Cl-]
• Uses: 4-aminophenyldichloroarsine is a useful reagent for the study of 2-oxoacid dehydrogenase multienzyme complexes.

Technology Process of 4-Aminophenyldichloroarsine

There total 2 articles about 4-Aminophenyldichloroarsine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

p-aminophenylarsonic acid (98-50-0) → p-aminophenyldichloroarsine. hydrochloride (5410-78-6)

Guidance literature:

With hydrogenchloride; sulfur dioxide; potassium iodide; In methanol; at 20 ℃; for 0.75h;

DOI:10.1016/j.tetlet.2012.10.070

Reference yield: 98.0%

p-arsanilic acid → p-aminophenyldichloroarsine. hydrochloride (5410-78-6)

Guidance literature:

With hydrogenchloride; sulfur dioxide; potassium iodide; In methanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2008.03.054

Reference yield: 82.0%

ethane-1,2-dithiol (540-63-6) + p-aminophenyldichloroarsine. hydrochloride (5410-78-6) → 4-(1,3,2-dithiocycloarsenic-2-yl)aniline (5577-20-8)

Guidance literature:

With sodium hydrogencarbonate; In methanol; water;

DOI:10.1039/C8RA07860B

upstream raw materials:

p-aminophenylarsonic acid

Downstream raw materials:

4-aminophenylarsenoxide

aniline

C₂₇H₂₈AsN₃O₃S₂

4-(1,3,2-dithiocycloarsenic-2-yl)aniline

Refernces

• 1、 -. "With anti-tumor activity of arsenic saccharification composition and its preparation and use". Paragraph 0025. . Retrieved 2018/04/01.
• 2、 Liu, Yaping,Duan, Dongzhu,Yao, Juan,Zhang, Baoxin,Peng, Shoujiao,Ma, Huilong,Song, Yanlin,Fang, Jianguo. "Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase". supporting information. p. 5203 - 5211. Retrieved 2014/07/08.