Me3SnOH

Base Information

• Chemical Name: Me3SnOH
• CAS No.: 56-24-6
• Molecular Formula: C3H10 O Sn
• Molecular Weight: 180.822
• Wikidata: Q27251132
• Mol file: 56-24-6.mol

Synonyms:Me3SnOH;trimethylstannanylium;hydroxide;SCHEMBL206415;OJZNYUDKNVNEMV-UHFFFAOYSA-M;AKOS025293865;Q27251132

Chemical Property of Me3SnOH

Chemical Property:

• Melting Point: 118°C
• Boiling Point: 80°C
• PKA: 6.36±0.70(Predicted)
• Flash Point: °C
• PSA: 20.23000
• Density: g/cm³
• LogP: 0.81360
• Sensitive.: Moisture Sensitive
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 181.975367
• Heavy Atom Count: 5
• Complexity: 8

Purity/Quality:

98%,99%, ^*data from raw suppliers

TrimethyltinHydroxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): A poison. TWA 0.1 mg(Sn)/m³; STEL 0.2 mg(Sn)/m³ (skin).
• Hazard Codes: T+:Very toxic
• Statements: 20/21/22
• Safety Statements: 22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Sn+](C)C.[OH-]
• Uses: Drug. Trimethyltin hydroxide is used in the synthesis of modified thymines, which is useful as inhibitors of RNase A. It is also used in the preparation of ketoheterocycle inhibitors of fatty acid amide inhibitors. It reacts with 2,2-disubstituted benzothiazolines to form trialkyltin derivatives of sulphur containing Schiff base complexes.

Technology Process of Me3SnOH

There total 43 articles about Me3SnOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(CH3)3SnCH2C6H4-m-Cl (27640-06-8) → trimethyltin(IV) hydroxide (56-24-6)

Guidance literature:

With sodium hydroxide; In ethanol; water; byproducts: m-chlorotoluene; refluxing for 52 h;;

Reference yield: 63.0%

2,6-dichloro-1,4-benzoquinone (697-91-6) + hexamethyldistannane (661-69-8) → C6Cl2H2(OSn(CH3)3)2 (76279-09-9) + trimethyltin(IV) hydroxide (56-24-6)

Guidance literature:

In benzene; keeping at room temp. (N2) for 4 d; various yields in various conditions; evapn.; elem. anal.;

Reference yield: 47.0%

tris(trimethylstannyl)stibine (7029-29-0) → bis(trimethyltin)oxide (1692-18-8) + tetrakis(trimethylstannyl)distibane (68354-51-8) + trimethyltin(IV) hydroxide (56-24-6)

Guidance literature:

With oxygen; In neat (no solvent); stibane left in air for 3 d; suspending in Ar-satd. acetone, decanting, recrystn. of red residue from toluene (2nd and 3rd product isolated from acetone suspn.); elem. anal.;

upstream raw materials:

trimethyl(trimethylstannyl)silane

trimethyltin bromide

(pentafluorophenyl)trimethyltin

2-(trimethylstannyl)-1-methylimidazole

Downstream raw materials:

tetramethylstannane

(CH₃)3SnSOCC₆H₄COSSn(CH₃)3

Trimethylzinnisocyanat

trimethyltin(IV)di(4-chlorobenzenesulfonyl)amide

Refernces

• 1、 Seyferth et al.. "-". . p. 1954. Retrieved 1969.
• 2、 Kriegsmann et al.. "-". . p. 283,288. Retrieved 1962.
• 3、 Nath, Mala,Jairath, Ruchi,Eng, George,Song, Xueqing,Kumar, Ashok. "New organotin(IV) ascorbates: Synthesis, spectral characterization, biological and potentiometric studies". . p. 77 - 86. Retrieved 2007/10/03.
• 4、 Pandolfo, Luciano,Paiaro, Gastone. "Reactions of Carbon Suboxide with Hydrides". . p. 531 - 534. Retrieved 2007/10/02.