Adipamide

Base Information

• Chemical Name: Adipamide
• CAS No.: 628-94-4
• Molecular Formula: C6H12 N2 O2
• Molecular Weight: 144.173
• Hs Code.: 29241900
• European Community (EC) Number: 211-062-5
• NSC Number: 7623
• UNII: 40DRU033OW
• DSSTox Substance ID: DTXSID4020032
• Nikkaji Number: J6.884E
• Wikipedia: Adipamide
• Wikidata: Q4115289
• Metabolomics Workbench ID: 71512
• ChEMBL ID: CHEMBL1416640
• Mol file: 628-94-4.mol

Synonyms:adipamide

Chemical Property of Adipamide

Chemical Property:

• Appearance/Colour: powder
• Vapor Pressure: 5.87E-08mmHg at 25°C
• Melting Point: 226-229 °C(lit.)
• Refractive Index: 1.4500 (estimate)
• Boiling Point: 412.4°C at 760 mmHg
• PKA: 16.26±0.40(Predicted)
• Flash Point: 203.2°C
• PSA: 86.18000
• Density: 1.18g/cm³
• LogP: 0.91800
• Storage Temp.: Store below +30°C.
• Solubility.: formic acid: soluble50mg/mL, clear, colorless to faintly yellow
• Water Solubility.: 4.4g/L(12.20 oC)
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 144.089877630
• Heavy Atom Count: 10
• Complexity: 118

Purity/Quality:

98%,99%, ^*data from raw suppliers

Adipamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: C(CCC(=O)N)CC(=O)N
• Description: Adipamide is a chunky white powder. It is slightly soluble in water and incompatible with strong oxidising agents. Adipamide on combustion and decomposition produces hazardous products of toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides. Exposures to adipamide by inhalation, ingestion, or skin absorption cause adverse health. The symptoms include irritation of the eyes, skin, mucous membranes, and upper respiratory tract. There is no complete information about the toxicological properties of the chemical.
• Uses: Adipamide has been used in the preparation of bisimidates.

Technology Process of Adipamide

There total 50 articles about Adipamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

hexanedinitrile (111-69-3) → adipamide (628-94-4)

Guidance literature:

With [RuH(tBu-PNP(-))(CO)]; water; In tert-butyl alcohol; at 50 ℃; for 24h;

DOI:10.1039/c9sc04624k

Reference yield: 99.0%

hexanedinitrile (111-69-3) → 5-cyanovaleramide (2304-58-7) + adipamide (628-94-4)

Guidance literature:

With sodium hydroxide; tricyclohexylphosphine; {Rh(OMe)(cod)}2; In isopropyl alcohol; at 25 ℃; for 48h;

DOI:10.1002/anie.200800366

Reference yield: 89.0%

carbon monoxide (201230-82-2) + buta-1,3-diene (106-99-0,130983-70-9,29406-96-0,9003-17-2) → adipamide (628-94-4)

Guidance literature:

With sodium tetrachloropalladate(II); ammonium chloride; In tetrachloromethane; at 50 ℃; for 20h; under 75007.5 Torr; Reagent/catalyst; Pressure; Solvent; Temperature; Autoclave;

upstream raw materials:

Adipic acid

hexanedioic acid dimethyl ester

hexanedinitrile

formamide

Downstream raw materials:

hexanedinitrile

1,4-diaminobutane

Adipic acid

caprolactam

Refernces

• 1、 Hartman,Wold. "". . p. 2439,2441,2442. Retrieved 1967.
• 2、 -. "METHOD FOR PRODUCING ADIPAMIDE AS INTERMEDIATE FOR PRODUCTION OF RAW MATERIAL FOR BIO-BASED NYLON". Paragraph 0064-0084. . Retrieved 2020/03/17.
• 3、 Guo, Beibei,Otten, Edwin,De Vries, Johannes G.. "Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst". . p. 10647 - 10652. Retrieved 2019/12/02.