3,5-Bis(bromomethyl)toluene

Base Information

• Chemical Name: 3,5-Bis(bromomethyl)toluene
• CAS No.: 19294-04-3
• Molecular Formula: C9H10Br2
• Molecular Weight: 277.986
• Hs Code.: 2903999090
• Mol file: 19294-04-3.mol

Synonyms:Mesitylene,a,a'-dibromo- (8CI);Mesitylene, a1,a3-dibromo- (6CI);1,3-Bis(bromomethyl)-5-methylbenzene;1,3-Di(bromomethyl)-5-methylbenzene;3,5-Bis(bromomethyl)toluene;5-Methyl-1,3-bis(bromomethyl)benzene;5-Methyl-1,3-di(bromomethyl)benzene;NSC 243652;a,a'-Dibromomesitylene;

Chemical Property of 3,5-Bis(bromomethyl)toluene

Chemical Property:

• Vapor Pressure: 2.08mmHg at 25°C
• Melting Point: 64-67℃
• Refractive Index: 1.43
• Boiling Point: 293.3°Cat760mmHg
• Flash Point: 149.8°C
• PSA: 0.00000
• Density: 1.687g/cm³
• LogP: 3.78480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Sparingly), Methanol (Sparingly)
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

1,?3-?Bis(bromomethyl)?-?5-?methylbenzene ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,?3-?Bis(bromomethyl)?-?5-?methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity

Technology Process of 3,5-Bis(bromomethyl)toluene

There total 7 articles about 3,5-Bis(bromomethyl)toluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,3,5-trimethyl-benzene (108-67-8) → 3,5-bis(bromomethyl)toluene (19294-04-3)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In benzene; at 85 ℃; for 12h;

DOI:10.1246/cl.2007.888

Reference yield: 39.0%

1,3,5-trimethyl-benzene (108-67-8) → 3,5-bis(bromomethyl)toluene (19294-04-3) + 1,3,5-Tris(bromomethyl)benzene (18226-42-1)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In cyclohexane; for 0.5h; Product distribution / selectivity; Heating / reflux;

Reference yield:

1,3-bis-(hydroxymethyl)-5-methylbenzene (27711-63-3) → 3,5-bis(bromomethyl)toluene (19294-04-3)

Guidance literature:

With hydrogen bromide;

upstream raw materials:

1,3-bis-(hydroxymethyl)-5-methylbenzene

1,3,5-trimethyl-benzene

1-bromomethyl-3,5-dimethylbenzene

Downstream raw materials:

(3-cyanomethyl-5-methyl-phenyl)-acetonitrile

1,3,5-Tris(bromomethyl)benzene

1,3-Bis-<2,2-dicarbethoxy-penten-(4)-yl>-5-methyl-benzol

1,3-bis-acetoxymethyl-5-methyl-benzene

Refernces

• 1、 You, XiuLi,Wei, ZhenHong,Wang, HaiLong,Li, DongPing,Liu, Jian,Xu, BeiBei,Liu, Xiaoming. "Synthesis of two copper clusters and their catalysis towards the oxidation of benzene into phenol". . p. 61790 - 61798. Retrieved 2015/02/19.
• 2、 Shimizu, Tomoe,Hita, Katsuhiro,Rahman, Shofiur,Yamato, Takehiko. "Synthesis of 8-methyl[2.2]metacyclophanes and their charge-transfer complexes with tetracyanoethylene". experimental part. p. 293 - 297. Retrieved 2009/12/07.