(2-Aminoacetyl)azanium;chloride

Base Information

• Chemical Name: (2-Aminoacetyl)azanium;chloride
• CAS No.: 1668-10-6
• Molecular Formula: C2H6N2O^.HCl
• Molecular Weight: 110.543
• Hs Code.: 29241900
• Mol file: 1668-10-6.mol

Synonyms:

Chemical Property of (2-Aminoacetyl)azanium;chloride

Chemical Property:

• Appearance/Colour: Crystalline
• Vapor Pressure: 0.00359mmHg at 25°C
• Melting Point: 204 °C (dec.)(lit.)
• Boiling Point: 281.3 °C at 760 mmHg
• PKA: 8.20(at 20℃)
• Flash Point: 123.9 °C
• PSA: 69.11000
• Density: 1.122 g/cm³
• LogP: 0.63300
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: H2O: 0.1 g/mL, clear
• Water Solubility.: Soluble in water (1100g/L).
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 110.0246905
• Heavy Atom Count: 6
• Complexity: 42.9

Purity/Quality:

99% ^*data from raw suppliers

Glycinamide Hydrochloride >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)[NH3+])N.[Cl-]
• Uses: Glycinamide hydrochloride is a buffer that is useful in the physiological pH range. And it is also used as a pharmaceutical intermediate, in the organic synthesis. Glycinamide hydrochloride may be used in the synthesis of [M(glycinamidato-N,N′)(ptpy)2] where ptpy = 2-(p-tolyl)pyridinato) and M= Rh or Ir. It may be used in the synthesis of the following glycinamide-based imidazolidinones:(±)-2-(2-phenylpropyl)imidazolidin-4-one(±)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one (±)-2-[(R)-2,6-dimethyl-5-heptenyl]imidazolidin-4-one (5R,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one(5S,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one(±)-2-methyl-2-pentylimidazolidin-4-one(±)-2-ethyl-2-(2-methylbutyl)imidazolidin-4-one (±)-2-(undecan-2-yl)imidazolidin-4-one (±)-2-pentylimidazolidin-4-one 2-(2,4-dimethylcyclohex-3-en-1-yl)imidazolidin-4-one

Technology Process of (2-Aminoacetyl)azanium;chloride

There total 10 articles about (2-Aminoacetyl)azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-aminoacetonitrile (540-61-4) → glycinamide hydrochloride (1668-10-6)

Guidance literature:

With hydrogenchloride; 2-hydroxyethanethiol; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(00)88755-9

Reference yield: 76.0%

Chloroacetamide (79-07-2) → glycinamide hydrochloride (1668-10-6)

Guidance literature:

With ammonia; In ethanol; at 100 ℃; for 0.5h;

DOI:10.1039/c9ra03693h

Reference yield: 73.0%

→ glycinamide hydrochloride (1668-10-6)

Guidance literature:

upstream raw materials:

2-aminoacetonitrile

4-methylene-1-oxa-6,9-diazaspiro<4,5>decane-7,10-dione

glycine ethyl ester hydrochloride

Chloroacetamide

Downstream raw materials:

N-(N-benzyloxycarbonyl-L-leucyl)-glycine amide

N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide

Boc-Phe-Gly-NH₂

Z-L-phenylalanylglycinamide

Refernces

• 1、 -. "REDUCING UNDESIRED POLYMERIZATION IN HYDROCARBON CRACKING PROCESSES". . . Retrieved 2009/01/20.
• 2、 -. "Preparation and purification of antiviral disulfonic acid disodium salt". . . Retrieved 2008/06/13.