2,4-difluoro-1,3-dimethoxybenzene

Base Information

• Chemical Name: 2,4-difluoro-1,3-dimethoxybenzene
• CAS No.: 195136-69-7
• Molecular Formula: C₈H₈F₂O₂
• Molecular Weight: 174.147
• Hs Code.: 2909309090
• Mol file: 195136-69-7.mol

Synonyms:2,4-difluoro-1,3-dimethoxybenzene

Chemical Property of 2,4-difluoro-1,3-dimethoxybenzene

Chemical Property:

• Boiling Point: 230.2±35.0 °C(Predicted)
• Density: 1.193±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

1,3-Dimethoxy-2,4-difluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-difluoro-1,3-dimethoxybenzene

There total 6 articles about 2,4-difluoro-1,3-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-amino-3,5-difluoro-2,4-dimethoxybenzene (195136-67-5) → 2,4-difluoro-1,3-dimethoxybenzene (195136-69-7)

Guidance literature:

With hydrogenchloride; hypophosphorous acid; sodium nitrite; In water; at 0 - 5 ℃; Inert atmosphere;

DOI:10.1021/jo500219y

Reference yield:

hexafluorophosphoric acid + 1-amino-3,5-difluoro-2,4-dimethoxybenzene (195136-67-5) → 2,4-difluoro-1,3-dimethoxybenzene (195136-69-7)

Guidance literature:

With sodium hydroxide; In P₂ O₅;

Reference yield:

1,3-difluoro-2,4-dimethoxy-5-nitrobenzene (195136-63-1) → 2,4-difluoro-1,3-dimethoxybenzene (195136-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99.8 percent / H₂ / Pd/C / ethanol; ethyl acetate / 2068.6 Torr

2: 1.) NaNO₂, HCl, 2.) H₃PO₂ / 1.) H₂O, 15 min, 2.) H₂O, 4 deg C, overnight, 20 deg C, 2 h

With hydrogenchloride; hydrogen; hypophosphorous acid; sodium nitrite; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jo9706178

upstream raw materials:

1-amino-3,5-difluoro-2,4-dimethoxybenzene

2,3,4,5-tetrafluoro-1-nitrobenzene

1,3-difluoro-2,4-dimethoxy-5-nitrobenzene

hypophosphorous acid

Downstream raw materials:

2′,4′,5′,7′-tetrafluoro-3′,6′-dihydroxy-5,10-diphenyl-3H-spiro-[anthra[2,3-c]furan-1,9′-xanthen]-3-one

3,5-Difluoro-2,4-dihydroxybenzaldehyde

6,8-difluoro-7-hydroxycoumarin-3-carboxylic acid

6,8-difluoro-7-hydroxy-4-methyl-2H-chromen-2-one

Refernces

• 1、 Kerkovius, Jeff K.,Menard, Frederic. "A Practical Synthesis of 6,8-Difluoro-7-hydroxycoumarin Derivatives for Fluorescence Applications". . p. 1622 - 1629. Retrieved 2016/05/24.
• 2、 Hedberg, Christian,Dekker, Frank J.,Rusch, Marion,Renner, Steffen,Wetzel, Stefan,Vartak, Nachiket,Gerding-Reimers, Claas,Bon, Robin S.,Bastiaens, Philippe I. H.,Waldmann, Herbert. "Development of highly potent inhibitors of the ras-targeting human acyl protein thioesterases based on substrate similarity design". supporting information; experimental part. p. 9832 - 9837. Retrieved 2011/12/02.