Technology Process of (S)-2-benzyloxycarbonylaminopentanal
There total 2 articles about (S)-2-benzyloxycarbonylaminopentanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzyl N-[(1S)-1-(hydroxymethyl)butyl]carbamate;
With
sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide; toluene;
at 0 ℃;
for 1h;
Inert atmosphere;
With
sodium hypochlorite; sodium hydrogencarbonate; sodium bromide;
In
dimethyl sulfoxide; toluene;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / 6 h / Reflux; Inert atmosphere
2.1: potassium carbonate / water; tetrahydrofuran / 4 h / 20 °C
2.2: 2 h / 10 - 25 °C
3.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / toluene; dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere
3.2: 1 h / 0 °C
With
hydrogenchloride; sulfur trioxide pyridine complex; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; water; dimethyl sulfoxide; toluene;
- Guidance literature:
-
With
D-fructose-6-phosphate aldolase from Escherichia coli;
In
N,N-dimethyl-formamide;
at 25 ℃;
pH=7.5;
diastereoselective reaction;
Enzymatic reaction;
DOI:10.1002/adsc.201500073
![benzyl N-[(1S)-1-(hydroxymethyl)butyl]carbamate](/Databaselist/images/loading.webp)
