Technology Process of (3S)-2-Hydroxy-3-[[(benzyloxy)carbonyl]aMino]hexanoic Acid Methyl Ester
There total 6 articles about (3S)-2-Hydroxy-3-[[(benzyloxy)carbonyl]aMino]hexanoic Acid Methyl Ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexane-1-nitrile;
With
hydrogenchloride; water;
for 3h;
Reflux;
methanol;
Reflux;
With
benzyl chloroformate;
In
tetrahydrofuran;
at 10 - 20 ℃;
for 3h;
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 40 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride / 6 h / Reflux; Inert atmosphere
2.1: potassium carbonate / water; tetrahydrofuran / 4 h / 20 °C
2.2: 2 h / 10 - 25 °C
3.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / toluene; dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere
3.2: 1 h / 0 °C
4.1: water; sodium dithionite / methanol / 0 °C / Cooling
4.2: 2 h / 25 °C
5.1: hydrogenchloride; water / 3 h / Reflux
5.2: Reflux
5.3: 3 h / 10 - 20 °C
With
hydrogenchloride; sodium dithionite; water; sulfur trioxide pyridine complex; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; toluene;
