2,2'-Dihydroxy-4,4'-dimethoxybenzophenone

Base Information

• Chemical Name: 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone
• CAS No.: 131-54-4
• Deprecated CAS: 862891-45-0
• Molecular Formula: C15H14O5
• Molecular Weight: 274.273
• Hs Code.: 29145090
• European Community (EC) Number: 205-027-3
• NSC Number: 40149
• UNII: 7813J9CS1G
• DSSTox Substance ID: DTXSID6038875
• Nikkaji Number: J8.632K
• Wikidata: Q27266628
• ChEMBL ID: CHEMBL1598017
• Mol file: 131-54-4.mol

Synonyms:131-54-4;2,2'-Dihydroxy-4,4'-dimethoxybenzophenone;Bis(2-hydroxy-4-methoxyphenyl)methanone;Benzophenone-6;Methanone, bis(2-hydroxy-4-methoxyphenyl)-;Cyasorb UV 12;Uvinul D 49;Caswell No. 353C;4,4'-Dimethoxy-2,2'-dihydroxybenzophenone;EINECS 205-027-3;NSC 40149;BRN 1887087;BENZOPHENONE, 2,2'-DIHYDROXY-4,4'-DIMETHOXY-;UNII-7813J9CS1G;DTXSID6038875;7813J9CS1G;NSC-40149;Uvinul D49;BENZOPHENONE 6;HELISORB 11;4,2'-dihydroxybenzophenone;Oprea1_596131;SCHEMBL38652;BENZOPHENONE-6 [MI];MLS000078302;BIDD:ER0037;BENZOPHENONE-6 [INCI];BENZOPHENONE-6 [MART.];CHEMBL1598017;DTXCID4018875;HSDB 8473;BENZOPHENONE-6 [WHO-DD];HMS1607E21;HMS2337I05;NSC40149;Tox21_200543;BBL027762;MFCD00009606;STK835235;AKOS001483238;CCG-103162;NCGC00066968-02;NCGC00258097-01;AS-14402;Bis(2-hydroxy-4-methoxyphenyl) methanone;CAS-131-54-4;LS-38907;SMR000034072;2,2'-dihydroxy-4,4'-dimethoxybenzophenon;bis(4-methoxy-2-oxidanyl-phenyl)methanone;Benzophenone,2'-dihydroxy-4,4'-dimethoxy-;2,2'-dihydroxy-4,4'-dimethoxy-benzophenone;CS-0204684;D0575;FT-0609242;2,2/'-Dihydroxy-4,4/'-dimethoxybenzophenone;2,2\'-Dihydroxy-4,4\'-dimethoxybenzophenone;D89680;2, 2'- dihydroxy- 4, 4'- dimethoxybenzophenone;2,2'-Dihydroxy-4,4'-dimethoxybenzophenone, 98%;A806281;SR-01000389299;2,2' - dihydroxy - 4,4' - dimethoxybenzophenone;2,2'-Dihydroxy-4,4'-dimethoxybenzophenone (8CI);SR-01000389299-1;W-108330;Q27266628

Chemical Property of 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone

Chemical Property:

• Appearance/Colour: Yellow crystalline powder
• Melting Point: 133-136 ºC
• Refractive Index: 1.5000 (estimate)
• Boiling Point: 439.3 ºC at 760 mmHg
• PKA: 6.81±0.35(Predicted)
• Flash Point: 164.4 ºC
• PSA: 75.99000
• Density: 1.291 g/cm³
• LogP: 2.34600
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Heated)
• Water Solubility.: negligible
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 274.08412354
• Heavy Atom Count: 20
• Complexity: 302

Purity/Quality:

99%, ^*data from raw suppliers

2,2''-Dihydroxy-4,4''-dimethoxybenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)C2=C(C=C(C=C2)OC)O)O
• Uses: As ultraviolet light absorber, especially in paints, plastics.

Technology Process of 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone

There total 10 articles about 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) → bis(2-hydroxy-4-methoxyphenyl)-methanone (131-54-4)

Guidance literature:

With dicarbonyl(acetylacotonato)rhodium(I); copper(II) acetate monohydrate; sodium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c6ra18647e

Reference yield: 41.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + salicylaldehyde (90-02-8) → bis(2-hydroxy-4-methoxyphenyl)-methanone (131-54-4) + 2,2'-dihydroxybenzophenone (835-11-0) + (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-methanone (131-53-3)

Guidance literature:

With dicarbonyl(acetylacotonato)rhodium(I); copper(II) acetate monohydrate; sodium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c6ra18647e

Reference yield: 10.0%

O-methylresorcine (150-19-6) + [(bromodifluoromethyl)sulfanyl]benzene (78031-08-0) → bis(2-hydroxy-4-methoxyphenyl)-methanone (131-54-4)

Guidance literature:

[(bromodifluoromethyl)sulfanyl]benzene; With titanium tetrachloride; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

O-methylresorcine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201100715

upstream raw materials:

O-methylresorcine

4-methoxysalicylic acid

2,2',4,4'-tetramethoxybenzophenone

2,4-dimethoxybenzoyl chloride

Downstream raw materials:

2,2',4,4'-tetrahydroxybenzophenone

2,2',4,4'-tetramethoxybenzophenone

2,2'-dihydroxy-4,4'-dimethoxybenzophenone-5,5'-disulfonic acid

(2,4-dihydroxyphenyl)(2-hydroxy-4-methoxyphenyl)methanone

Refernces

• 1、 -. "Water-soluble ultraviolet absorbent BP-9 method for the synthesis of (by machine translation)". Paragraph 0006; 0025; 0026. . Retrieved 2017/01/17.
• 2、 -. "A composition for lightening skin and hair". . . Retrieved 2014/10/28.