(2,4-Dimethoxyphenyl)acetone

Base Information

• Chemical Name: (2,4-Dimethoxyphenyl)acetone
• CAS No.: 831-29-8
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Hs Code.: 2914509090
• Mol file: 831-29-8.mol

Synonyms:2,4-Dimethoxybenzyl methyl ketone;2-Propanone,(2,4-dimethoxyphenyl)- (7CI);

Chemical Property of (2,4-Dimethoxyphenyl)acetone

Chemical Property:

• Vapor Pressure: 0.00228mmHg at 25°C
• Refractive Index: n20/D 1.529(lit.)
• Boiling Point: 288.8 °C at 760 mmHg
• Flash Point: 119.3 °C
• PSA: 35.53000
• Density: 1.056 g/cm³
• LogP: 1.83530

Purity/Quality:

99% ^*data from raw suppliers

1-(2,4-dimethoxyphenyl)propan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2,4-Dimethoxyphenyl)acetone

There total 5 articles about (2,4-Dimethoxyphenyl)acetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2,4-Dimethoxy-phenyl)-propan-2-one O-methyl-oxime (94169-20-7) → 1-(2,4-dimethoxyphenyl)propan-2-one (831-29-8)

Guidance literature:

With hydrogenchloride; In methanol; at 65 ℃; for 10h;

DOI:10.1039/c39840000795

Reference yield:

(E)-2,4-dimethoxy-1-(prop-1-en-1-yl)benzene (50900-55-5) → 2,4-dimethoxypropiophenone (831-00-5) + 1-(2,4-dimethoxyphenyl)propan-2-one (831-29-8)

Guidance literature:

With water; oxygen; copper(l) iodide; palladium dichloride; In N,N-dimethyl-formamide; at 50 ℃; for 24h; Title compound not separated from byproducts.;

DOI:10.1039/b103066n

Reference yield:

2,4-dimethoxybenzophenone (3555-84-8) → 1-(2,4-dimethoxyphenyl)propan-2-one (831-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.25 h / Inert atmosphere

1.2: 1.42 h / 40 °C / Inert atmosphere

2.1: 2-Iodo-5-methylbenzenesulfonic acid / water; tert-butyl methyl ether; isopropyl alcohol / 0.5 h / 0 - 5 °C / Inert atmosphere

2.2: 2.25 h / 20 °C / Inert atmosphere

With 2-Iodo-5-methylbenzenesulfonic acid; In tetrahydrofuran; tert-butyl methyl ether; water; isopropyl alcohol; 1.1: |Wittig Olefination;

DOI:10.1021/ol400432x

upstream raw materials:

1-(2,4-Dimethoxy-phenyl)-propan-2-one O-methyl-oxime

1-(2,4-Dimethoxyphenyl)-2-nitropropen

1-Bromo-2,4-dimethoxybenzene

acetone

Downstream raw materials:

(3E)-3-(2,4-dimethoxyphenyl)-4-(dimethylamino)but-3-en-2-one

5-(2,4-dimethoxy-phenyl)-6-methyl-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile

2,3,5,6-tetraphenylpyrazine

2,4-dimethoxyamphetamine

Refernces

• 1、 Gaunt,Yu,Spencer. "Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation". . p. 1844 - 1845. Retrieved 2007/10/03.