acetic acid 2,4,5-trimethyl-benzyl ester

Base Information

• Chemical Name: acetic acid 2,4,5-trimethyl-benzyl ester
• CAS No.: 18543-92-5
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.258
• Mol file: 18543-92-5.mol

Synonyms:acetic acid 2,4,5-trimethyl-benzyl ester

Chemical Property of acetic acid 2,4,5-trimethyl-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of acetic acid 2,4,5-trimethyl-benzyl ester

There total 10 articles about acetic acid 2,4,5-trimethyl-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1,2,4,5-tetramethylbenzene (95-93-2) → acetic acid 2,4,5-trimethyl-benzyl ester (18543-92-5) + 2,4,5-trimethylbenzaldehyde (5779-72-6)

Guidance literature:

With air; copper diacetate; cobalt(II) acetate; acetic acid; sodium bromide; at 150 ℃; for 1h; under 15200 Torr;

DOI:10.1246/bcsj.54.2724

Reference yield: 10.0%

1,2,4,5-tetramethylbenzene (95-93-2) + acetic acid (64-19-7,77671-22-8) → acetic acid 2,4,5-trimethyl-benzyl ester (18543-92-5) + 2,4,5-trimethylbenzaldehyde (5779-72-6)

Guidance literature:

With air; copper diacetate; cobalt(II) acetate; sodium bromide; at 150 ℃; for 1h; under 15200 Torr;

DOI:10.1246/bcsj.54.2724

Reference yield:

1,2,4,5-tetramethylbenzene (95-93-2) → 2,3,5,6-tetramethyliodobenzene (2100-25-6) + acetic acid 2,4,5-trimethyl-benzyl ester (18543-92-5)

Guidance literature:

With ammonium peroxydisulfate; copper diacetate; iodine; trifluoroacetic acid; trifluoroacetic anhydride; In acetic acid; acetonitrile; for 24h; Product distribution; Mechanism; Ambient temperature; aromatic iodination: competition reaction with mesitylene: k_MES/k_DUR; other conc. other times; or with Et₄NI, NaNO₃, O₂;

DOI:10.1021/jo00010a013

upstream raw materials:

2,4,5-trimethylbenzaldehyde

acetic acid

1,2,4,5-tetramethylbenzene

1,2,4-Trimethylbenzene

Downstream raw materials:

2,4,5-trimethyl-benzyl alcohol

(2,4,5-trimethyl-3,6-dinitro-phenyl)-acetic acid

2,4,5-trimethylbenzyl chloride

(2,4,5-trimethyl-phenyl)-acetic acid

Refernces

• 1、 Khenkin, Alexander M.,Neumann, Ronny. "Oxidation of alkylarenes by nitrate catalyzed by polyoxophosphomolybdates: Synthetic applications and mechanistic insights". . p. 6356 - 6362. Retrieved 2007/10/03.
• 2、 Okada, Toshihiko,Kamiya, Yoshio. "The Liquid-phase Oxidation of the Methylbenzenes by the Cobalt-Copper-Bromide System". . p. 2724 - 2727. Retrieved 2007/10/02.