1-(2,4,5-trimethoxyphenyl)-1-propanol

Base Information

• Chemical Name: 1-(2,4,5-trimethoxyphenyl)-1-propanol
• CAS No.: 834-93-5
• Molecular Formula: C12H18 O4
• Molecular Weight: 226.26892
• Hs Code.: 2909499000
• Mol file: 834-93-5.mol

Synonyms:Benzylalcohol, a-ethyl-2,4,6-trimethoxy- (7CI,8CI)

Chemical Property of 1-(2,4,5-trimethoxyphenyl)-1-propanol

Chemical Property:

• PSA: 47.92000
• LogP: 2.15580

Purity/Quality:

98.00% ^*data from raw suppliers

1-(2,4,5-Trimethoxyphenyl)-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,4,5-trimethoxyphenyl)-1-propanol

There total 5 articles about 1-(2,4,5-trimethoxyphenyl)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl bromide (74-96-4) + 2,4,6-trimethoxybenzaldehyde (830-79-5) → 1,3,5-trimethoxy-2-(1-hydroxypropyl)benzene (834-93-5)

Guidance literature:

ethyl bromide; With magnesium; In diethyl ether; for 2h;

2,4,6-trimethoxybenzaldehyde; In diethyl ether; toluene; at 20 ℃;

DOI:10.1246/bcsj.77.2231

Reference yield: 80.0%

2,4,6-trimethoxybenzaldehyde (830-79-5) + ethylmagnesium bromide (925-90-6) → 1,3,5-trimethoxy-2-(1-hydroxypropyl)benzene (834-93-5)

Guidance literature:

With iodine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 53.0%

1,2,3-trimethoxybenzene (621-23-8) + propionaldehyde (123-38-6) → 2-n-propyl-1,3,5-trimethoxybenzene (2215-97-6) + 1,3,5-trimethoxy-2-(1-hydroxypropyl)benzene (834-93-5)

Guidance literature:

With aluminum tri-bromide; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c4ob02597k

upstream raw materials:

2,4,6-trimethoxybenzaldehyde

ethylmagnesium bromide

ethyl bromide

1,2,3-trimethoxybenzene

Downstream raw materials:

(E)-1,3,5-trimethoxy-2-(prop-1-en-1-yl)benzene

Refernces

• 1、 Sharma, Anuj,Joshi, Bhupendra P.,Sinha, Arun K.. "An effective system to synthesize hypolipidemic active α-asarone and related methoxylated (E)-arylalkenes". . p. 2231 - 2235. Retrieved 2007/10/03.
• 2、 Poplawski,Lozowicka,Dubis,Lachowska,Witkowski,Siluk,Petrusewicz,Kaliszan,Cybulski,Strzalkowska,Chilmonczyk. "Synthesis and hypolipidemic and antiplatelet activities of α-asarone isomers in humans (in vitro), mice (in vivo), and rats (in vivo)". . p. 3671 - 3676. Retrieved 2007/10/03.