Technology Process of 2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide
There total 8 articles about 2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
silica gel;
In
1,4-dioxane;
for 0.05h;
microwave irradiation;
DOI:10.1246/bcsj.77.2231
- Guidance literature:
-
With
potassium tert-butylate; tetrabutylammomium bromide;
In
N,N-dimethyl-formamide;
at 0 - 95 ℃;
for 4.5h;
Inert atmosphere;
DOI:10.1016/j.bioorg.2021.105179
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: magnesium / diethyl ether / 2 h
1.2: 81 percent / diethyl ether; toluene / 20 °C
2.1: 64 percent / silica gel / dioxane / 0.05 h / microwave irradiation
With
silica gel; magnesium;
In
1,4-dioxane; diethyl ether;
1.2: Grignard reaction;
DOI:10.1246/bcsj.77.2231