1-(2,4,6-Trimethoxyphenyl)propan-2-one

Base Information

• Chemical Name: 1-(2,4,6-Trimethoxyphenyl)propan-2-one
• CAS No.: 835-25-6
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Mol file: 835-25-6.mol

Synonyms:1-(2,4,6-Trimethoxyphenyl)propan-2-one;1-(2,4,6-Trimethoxyphenyl)-2-propanone

Chemical Property of 1-(2,4,6-Trimethoxyphenyl)propan-2-one

Chemical Property:

• Melting Point: 87-88 °C
• Boiling Point: 328.2±37.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.078±0.06 g/cm3(Predicted)
• LogP: 1.84390
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2,4,6-Trimethoxyphenyl)acetone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,4,6-Trimethoxyphenyl)propan-2-one

There total 9 articles about 1-(2,4,6-Trimethoxyphenyl)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

1,2,3-trimethoxybenzene (621-23-8) + acetone (67-64-1) → 1-(2,4,6-trimethoxyphenyl)propan-2-one (835-25-6) + 1,1-bis(2,4,6-trimethoxyphenyl)propan-2-one

Guidance literature:

With tert.-butylhydroperoxide; methanesulfonic acid; In decane; at 40 ℃; for 15h;

DOI:10.1002/chem.201901439

Reference yield:

(E)-1,3,5-trimethoxy-2-(prop-1-en-1-yl)benzene (5273-96-1) → 1-(2,4,6-trimethoxyphenyl)propan-1-one (834-94-6) + 1-(2,4,6-trimethoxyphenyl)propan-2-one (835-25-6)

Guidance literature:

With water; oxygen; copper(l) iodide; palladium dichloride; In N,N-dimethyl-formamide; at 50 ℃; for 24h; Title compound not separated from byproducts.;

DOI:10.1039/b103066n

Reference yield:

1-(2,4,6-trimethoxyphenyl)-2-nitro-1-propene (78904-45-7) → 1-(2,4,6-trimethoxyphenyl)propan-2-one (835-25-6)

Guidance literature:

With hydrogenchloride; iron(III) chloride; iron;

upstream raw materials:

1-(2,4,6-trimethoxyphenyl)-2-nitro-1-propene

1-(2,4,6-trimethoxyphenyl)propan-2-ol

<4-Hydroxy-2,6-dimethoxy-phenyl>-aceton

dimethyl sulfate

Downstream raw materials:

1-(2,4,6-trimethoxyphenyl)propan-2-ol

2,4,6-trimethoxy-β-methyl-β-nitrostyrene

2-n-propyl-1,3,5-trimethoxybenzene

Refernces

• 1、 Gaunt,Yu,Spencer. "Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation". . p. 1844 - 1845. Retrieved 2007/10/03.