2-METHYL-3-CYANOMETHYL-6-METHOXY PYRIDINE

Base Information

• Chemical Name: 2-METHYL-3-CYANOMETHYL-6-METHOXY PYRIDINE
• CAS No.: 32383-10-1
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 153.181
• Hs Code.: 2933399090
• Mol file: 32383-10-1.mol

Synonyms:5-Cyanomethyl-2-methoxy-6-methylpyridine;

Chemical Property of 2-METHYL-3-CYANOMETHYL-6-METHOXY PYRIDINE

Chemical Property:

• Vapor Pressure: 0.00246mmHg at 25°C
• Refractive Index: 1.519
• Boiling Point: 287.6 °C at 760 mmHg
• PKA: 13.45±0.10(Predicted)
• Flash Point: 127.7 °C
• PSA: 45.91000
• Density: 1.087 g/cm³
• LogP: 1.46468
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(6-Methoxy-2-methylpyridin-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-3-CYANOMETHYL-6-METHOXY PYRIDINE

There total 6 articles about 2-METHYL-3-CYANOMETHYL-6-METHOXY PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

6-methoxy-2-methylpyridine-3-carboxaldehyde (156094-77-8) → 3-Hydroxymethyl-6-methoxy-2-methylpyridin (32383-10-1)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; In methanol; water; at 0 - 5 ℃;

Reference yield:

2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester (4027-39-8) → 3-Hydroxymethyl-6-methoxy-2-methylpyridin (32383-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 30 percent Pd/C

2: Ag₂CO₃ / tetrahydrofuran; benzene

3: LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; silver carbonate; 30% palladium on charcoal catalyst; In tetrahydrofuran; diethyl ether; benzene; 1: Catalytic oxidation / 2: Etherification / 3: Reduction;

Reference yield:

ethyl 2-(2-cyanoethyl)-3-oxobutanoate (10444-33-4) → 3-Hydroxymethyl-6-methoxy-2-methylpyridin (32383-10-1)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl / CHCl₃

2: 30 percent Pd/C

3: Ag₂CO₃ / tetrahydrofuran; benzene

4: LiAlH₄ / diethyl ether

With hydrogenchloride; lithium aluminium tetrahydride; silver carbonate; 30% palladium on charcoal catalyst; In tetrahydrofuran; diethyl ether; chloroform; benzene; 1: Cyclization / 2: Catalytic oxidation / 3: Etherification / 4: Reduction;

upstream raw materials:

ethyl 6-methoxy-2-methylnicotinate

2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester

ethyl 2-(2-cyanoethyl)-3-oxobutanoate

ethyl 2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Refernces

• 1、 -. "PROCESSES FOR THE PREPARATION OF PYRAZOLO[1,5-a]-1,3,5-TRIAZINES AND INTERMEDIATES THEREOF". Page/Page column 40; 41. . Retrieved 2010/02/11.