3-PHENOXYBENZALDEHYDE CYANOHYDRIN

Base Information

• Chemical Name: 3-PHENOXYBENZALDEHYDE CYANOHYDRIN
• CAS No.: 52315-06-7
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.247
• Mol file: 52315-06-7.mol

Synonyms:(RS)-a-Cyano-3-phenoxybenzyl alcohol;(m-Phenoxyphenyl)glycolonitrile;(?à)-a-Cyano-3-phenoxybenzyl alcohol;3-Phenoxy-a-cyanobenzyl alcohol;3-Phenoxybenzaldehyde cyanohydrin;3-Phenoxymandelonitrile;m-Phenoxybenzaldehyde cyanohydrin;m-Phenoxymandelonitrile;a-Cyano-3-phenoxybenzyl alcohol;a-Cyano-m-phenoxybenzyl alcohol;a-Hydroxy-3-phenoxybenzeneacetonitrile;

Chemical Property of 3-PHENOXYBENZALDEHYDE CYANOHYDRIN

Chemical Property:

• Vapor Pressure: 4.13E-07mmHg at 25°C
• Refractive Index: 1.606
• Boiling Point: 399.8 °C at 760 mmHg
• Flash Point: 195.6 °C
• PSA: 53.25000
• Density: 1.22g/cm³
• LogP: 3.03588
• Storage Temp.: 0-6°C

Purity/Quality:

99% ^*data from raw suppliers

3-Phenoxybenzaldehydecyanohydrin 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R11:Highly flammable.; R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
• Hazard Codes: F:Highly flammable
• Statements: R11:Highly flammable.; R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
• Safety Statements: S16:Keep away from sources of ignition - No smoking.; S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PHENOXYBENZALDEHYDE CYANOHYDRIN

There total 21 articles about 3-PHENOXYBENZALDEHYDE CYANOHYDRIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

hydrogen cyanide (74-90-8) + 3-Phenoxybenzaldehyde (39515-51-0) → (S)-m-phenoxybenzaldehyde cyanohydrin (39515-47-4,52315-06-7,61826-76-4,71962-66-8)

Guidance literature:

With hydroxynitrile lyase from Hevea brasiliensis; In water; at 15 ℃; for 0.25h; pH 5.5;

DOI:10.1016/S0040-4020(98)00901-6

Reference yield: 92.0%

O-acetyl-(S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile (113301-28-3) → (S)-m-phenoxybenzaldehyde cyanohydrin (39515-47-4,52315-06-7,61826-76-4,71962-66-8)

Guidance literature:

With ethanol; In di-isopropyl ether; at 25 ℃; for 6h; lipase from Pseudomonas cepacia (Amano);

DOI:10.1021/jo00047a016

Reference yield: 85.0%

(R,S)-cyano(3-phenoxyphenyl)methyl butyrate (120838-94-0) → (S)-m-phenoxybenzaldehyde cyanohydrin (39515-47-4,52315-06-7,61826-76-4,71962-66-8) + (R)-cyano(3-phenoxyphenyl)methyl butanoate

Guidance literature:

With Pseudomonas cepacia lipase immobilised in a gelatin matrix; butan-1-ol; In hexane; for 8h;

DOI:10.1016/S0957-4166(00)00303-7

upstream raw materials:

O-acetyl-(S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile

alpha-cyano-3-phenoxybenzyl acetate

(2R,4S)-4-Methyl-2-(3-phenoxy-phenyl)-[1,3]dioxane

(4S,6S)-4,6-Dimethyl-2-(3-phenoxy-phenyl)-[1,3]dioxane

Downstream raw materials:

esfenvalerate

[R]-alpha-cyano-3-phenoxybenzyl [S]-2-(4-chlorophenyl)-2-isopropyl-acetate

<1R,1α(S^*),3α(E)>-1-Cyano-1-(3-phenoxyphenyl)methyl 2,2-Dimethyl-3-<3-tert-butoxy-2-(tert-butylsulfonyl)-3-oxo-1-propenyl>cyclopropanecarboxylate

<1R,1α(S^*),3α(E)>-1-Cyano-1-(3-phenoxyphenyl)methyl 2,2-Dimethyl-3-<3-tert-butoxy-2-(phenylsulfonyl)-3-oxo-1-propenyl>cyclopropanecarboxylate

Refernces

• 1、 Jangir, Nisha,Padhi, Santosh Kumar. "Immobilized Baliospermum montanum hydroxynitrile lyase catalyzed synthesis of chiral cyanohydrins". . p. 32 - 40. Retrieved 2018/11/27.
• 2、 Chu, Chang-Ying,Hsu, Chu-Tin,Lo, Po Hsiang,Uang, Biing-Jiun. "Enantioselective silylcyanation of aldehydes catalyzed by new chiral oxovanadium complex". scheme or table. p. 1981 - 1984. Retrieved 2012/03/10.