6-Phenylpyridazin-3-amine

Base Information

• Chemical Name: 6-Phenylpyridazin-3-amine
• CAS No.: 14966-91-7
• Molecular Formula: C10H9N3
• Molecular Weight: 171.202
• Hs Code.: 2933990090
• European Community (EC) Number: 695-354-1
• DSSTox Substance ID: DTXSID70474739
• Nikkaji Number: J660.914G
• Wikidata: Q82304856
• Mol file: 14966-91-7.mol

Synonyms:6-phenylpyridazin-3-amine;14966-91-7;3-Amino-6-phenylpyridazine;MFCD00234636;3-Pyridazinamine, 6-phenyl-;6-Phenyl-3-pyridazinamine;3-Pyridazinamine,6-phenyl-;6-Phenyl-pyridazin-3-ylamine;SCHEMBL220069;DTXSID70474739;YTDZFWNQRRMELI-UHFFFAOYSA-N;(6-phenyl-pyridazin-3-yl)-amine;AKOS010128906;PS-3785;3-amino-6-phenylpyridazine, AldrichCPR;BP-11851;SY192738;CS-0156352;EN300-88808;A808938;J-518990;Z600584210

Chemical Property of 6-Phenylpyridazin-3-amine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 152 °C(Solv: water (7732-18-5))
• Refractive Index: 1.634
• Boiling Point: 403.006 °C at 760 mmHg
• PKA: 4.84±0.10(Predicted)
• Flash Point: 226.412 °C
• PSA: 51.80000
• Density: 1.193 g/cm³
• LogP: 2.30700
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 171.079647300
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

99% min ^*data from raw suppliers

6-Phenylpyridazin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NN=C(C=C2)N

Technology Process of 6-Phenylpyridazin-3-amine

There total 10 articles about 6-Phenylpyridazin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

6-bromopyridazin-3-amine (88497-27-2) + phenylboronic acid (98-80-6) → 3-amino-6-phenylpyridazine (14966-91-7)

Guidance literature:

With sodium carbonate; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In ethanol; toluene; for 18.5h; Reflux;

Reference yield: 80.0%

3-chloro-6-phenylpyradazine (20375-65-9) → 3-amino-6-phenylpyridazine (14966-91-7)

Guidance literature:

With ammonium carbonate; at 120 ℃; Ionic liquid; Microwave irradiation; Green chemistry;

DOI:10.1002/jhet.1623

Reference yield: 79.0%

6-chloro-pyridazin-3-ylamine (5469-69-2) + phenylboronic acid (98-80-6) → 3-amino-6-phenylpyridazine (14966-91-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; toluene; for 12h; Reflux;

upstream raw materials:

3-chloro-6-phenylpyradazine

3-phenylpyridazine

3-hydrazino-6-phenylpyridazine

C₂₈H₂₂N₃P

Downstream raw materials:

6-Amino-1-(3-carboxy-propyl)-3-phenyl-pyridazin-1-ium; bromide

4-bromo-6-phenylpyridazin-3-amine

N-(2-phenylethyl)-N'-(6-phenylpyridazin-3-yl)urea

N-(2-phenylethyl)-N'-(6-phenylpyridazin-3-yl)thiourea

Refernces

• 1、 -. "Asymmetric pyrene derivatives comprising amine group including heteroaryl group and naphthyl group and organic light-emitting diode including the same". Paragraph 0198; 0207-0210; 0320-0324. . Retrieved 2021/02/02.
• 2、 Kilic, Burcu,Gulcan, Hayrettin O.,Aksakal, Fatma,Ercetin, Tugba,Oruklu, Nihan,Umit Bagriacik,Dogruer, Deniz S.. "Design and synthesis of some new carboxamide and propanamide derivatives bearing phenylpyridazine as a core ring and the investigation of their inhibitory potential on in-vitro acetylcholinesterase and butyrylcholinesterase". . p. 235 - 249. Retrieved 2018/05/24.