4-Bromo-4'-methylbiphenyl

Base Information

• Chemical Name: 4-Bromo-4'-methylbiphenyl
• CAS No.: 50670-49-0
• Molecular Formula: C13H11Br
• Molecular Weight: 247.134
• Hs Code.: 2903999090
• Mol file: 50670-49-0.mol

Synonyms:Biphenyl,4-bromo-4'-methyl- (6CI);4-Bromo-4'-methyl-1,1'-biphenyl;4-Bromo-4'-methylbiphenyl;4'-Bromo-4-methylbiphenyl;

Chemical Property of 4-Bromo-4'-methylbiphenyl

Chemical Property:

• Melting Point: 136℃
• Boiling Point: 322.9 °C at 760 mmHg
• Flash Point: 148.2 °C
• PSA: 0.00000
• Density: 1.32 g/cm³
• LogP: 4.42450
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-4''-methylbiphenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-4'-methylbiphenyl is used as pharmaceutical intermediate.

Technology Process of 4-Bromo-4'-methylbiphenyl

There total 12 articles about 4-Bromo-4'-methylbiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,4-bromoiodobenzene (589-87-7) + 4-methylphenylboronic acid (5720-05-8) → 4-bromo-4'-methylbiphenyl (50670-49-0)

Guidance literature:

With sodium carbonate; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c6nj02345b

Reference yield: 88.0%

carbon monoxide (201230-82-2) + 4-methylphenylboronic acid (5720-05-8) + 4-bromobenzenediazonium tetrafluoroborate (673-40-5) → 4-bromo-4'-methylbiphenyl (50670-49-0) + (4-bromophenyl)(p-tolyl)methanone (76693-57-7)

Guidance literature:

With palladium diacetate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In 1,4-dioxane; at 100 ℃; for 5h; under 760 Torr;

DOI:10.1016/S0040-4039(02)02186-X

Reference yield: 68.0%

1,4-bromoiodobenzene (589-87-7) + p-tolyltriethoxysilane (18412-57-2) → 4-bromo-4'-methylbiphenyl (50670-49-0)

Guidance literature:

With copper(l) iodide; 2-benzhydryl-N,N-dimethylaniline; cesium fluoride; In N,N-dimethyl-formamide; at 120 ℃; for 48h; Sealed tube;

DOI:10.1055/s-0033-1339108

upstream raw materials:

α-(4-bromophenylazo)triphenylmethane

toluene

carbon monoxide

4-methylphenylboronic acid

Downstream raw materials:

4-Bromobenzoic acid

p-(p-tolyl)benzonitrile

4-(but-3-en-1-yl)-4'-methyl-1,1'-biphenyl

4,4,5,5-tetramethyl-2-(4'-methyl-[1,1'-biphenyl]-4-yl)-1,3,2-dioxaborolane

Refernces

• 1、 Antenucci, Achille,Barbero, Margherita,Dughera, Stefano,Ghigo, Giovanni. "Copper catalysed Gomberg-Bachmann-Hey reactions of arenediazonium tetrafluoroborates and heteroarenediazonium o-benzenedisulfonimides. Synthetic and mechanistic aspects". . . Retrieved 2020/10/20.
• 2、 Li, Fusheng,Zhao, Baodong,Chen, Yu,Zhang, Yufei,Wang, Tao,Xue, Song. "Synthesis, characterization, and nonlinear optical (NLO) properties of truxene-cored diphenylamine derivatives". . p. 20 - 26. Retrieved 2017/05/29.