(R)-(+)-1,2-Bis(diphenylphosphino)propane

Base Information

• Chemical Name: (R)-(+)-1,2-Bis(diphenylphosphino)propane
• CAS No.: 67884-32-6
• Molecular Formula: C27H26P2
• Molecular Weight: 412.451
• Hs Code.: 29310099
• European Community (EC) Number: 623-486-1
• DSSTox Substance ID: DTXSID50369154
• Nikkaji Number: J922.958B
• Wikidata: Q72445466
• Mol file: 67884-32-6.mol

Synonyms:67884-32-6;(R)-(+)-1,2-Bis(diphenylphosphino)propane;R-(+)-1,2-Bis(diphenylphosphino)propane;(R)-Propane-1,2-diylbis(diphenylphosphine);(R)-PROPHOS;(R)-(+)-BIS-(1,2-DIPHENYLPHOSPHINO)PROPANE;[(2R)-1-diphenylphosphanylpropan-2-yl]-diphenylphosphane;MFCD00012309;SCHEMBL613866;[(2R)-1-(diphenylphosphanyl)propan-2-yl]diphenylphosphane;DTXSID50369154;Phosphine, [(1R)-1-methyl-1,2-ethanediyl]bis[diphenyl-;Phosphine,1,1'-[(1R)-1-methyl-1,2-ethanediyl]bis[diphenyl-;AKOS015913500;CS-W009699;SC11384;R-(+)-1,2Bis(diphenylphosphino)propane;AS-65388;BP-12261;R-(+)-Bis(1,2-diphenylphosphino)propane;A835922;(R)-(+)-1,2-Bis(diphenylphosphino)propane, 98%;(R)-(+)-PROPHOS;(R)-(+)-PROPYLENEBIS(1,2-DIPHENYLPHOSPHINE);R-(+)-1,2-BIS(DIPHENYLPHOSPHINO)PROPANE

Chemical Property of (R)-(+)-1,2-Bis(diphenylphosphino)propane

Chemical Property:

• Appearance/Colour: White granular powder
• Vapor Pressure: 1.8E-10mmHg at 25°C
• Melting Point: 68-73 °C
• Boiling Point: 521.9 °C at 760 mmHg
• Flash Point: 286.4 °C
• PSA: 27.18000
• LogP: 5.64070
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: air sensitive
• XLogP3: 6.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 7
• Exact Mass: 412.15097482
• Heavy Atom Count: 29
• Complexity: 404

Purity/Quality:

99% ^*data from raw suppliers

R-(+)-1,2-Bis(diphenylphosphino)propane, 99% (R)-PROPHOS ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CP(C1=CC=CC=C1)C2=CC=CC=C2)P(C3=CC=CC=C3)C4=CC=CC=C4
• Isomeric SMILES: C[C@H](CP(C1=CC=CC=C1)C2=CC=CC=C2)P(C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of (R)-(+)-1,2-Bis(diphenylphosphino)propane

There total 2 articles about (R)-(+)-1,2-Bis(diphenylphosphino)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-(-)-1,2-propanediol ditosylate (60434-71-1) + triphenylphosphine (603-35-0) → R-Prophos (67884-32-6,67884-33-7)

Guidance literature:

Multistep reaction;

DOI:10.1021/ja00485a037

Reference yield:

→ R-Prophos (67884-32-6,67884-33-7)

Guidance literature:

Reference yield: 93.0%

silver hexafluoroantimonate (26042-64-8) + [RuCl2(hexamethylbenzene)]2 + R-Prophos (67884-32-6,67884-33-7) + water (7732-18-5) → [(η6-hexamethylbenzene)Ru((R)-propane-1,2-diylbis(diphenylphosphane))(H2O)][SbF6]2

Guidance literature:

In dichloromethane; acetone; byproducts: AgCl; under Ar; AgSbF6 added to suspn. of Ru complex in acetone-CH2Cl2; stirred at room temp. for 4 h; filtered; solid ligand added to filtrate at 0°C; stirred for 1 h; traces of water in acetone solvent; vac. concd. to dryness; dissolved in CH2Cl2; Et2O added slowly; filtered; solid washed with Et2O; vac. dried; elem. anal.;

DOI:10.1021/om200944y

upstream raw materials:

(2S)-(-)-1,2-propanediol ditosylate

triphenylphosphine

Downstream raw materials:

(R)-(+)-1,2-bis(diphenylphosphino)propane radical cation

((C₆H₅)2PCH(CH₃)CH₂P(C₆H₅)2)NiCH(CH₃)CH₂COO

((C₆H₅)2PCH(CH₃)CH₂P(C₆H₅)2)NiCH(CH₃)CH₂COO

((C₆H₅)2PCH(CH₃)CH₂P(C₆H₅)2)NiOOCCH₂CH(CH₃)

Refernces

• 1、 -. "Method for Producing Polyhydroxyalkanoates". . . Retrieved 2009/05/28.