O-(TRIMETHYLSILYL)HYDROXYLAMINE

Base Information

• Chemical Name: O-(TRIMETHYLSILYL)HYDROXYLAMINE
• CAS No.: 22737-36-6
• Molecular Formula: C3H11 N O Si
• Molecular Weight: 105.212
• Hs Code.: 29310099
• European Community (EC) Number: 626-309-6
• DSSTox Substance ID: DTXSID40370436
• Nikkaji Number: J1.838.385C
• Wikidata: Q72514492
• Mol file: 22737-36-6.mol

Synonyms:O-(Trimethylsilyl)hydroxylamine;Trimethylsiloxyamine

Chemical Property of O-(TRIMETHYLSILYL)HYDROXYLAMINE

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 39mmHg at 25°C
• Refractive Index: n20/D 1.405(lit.)
• Boiling Point: 98-100 °C(lit.)
• PKA: 3.28±0.70(Predicted)
• Flash Point: 48 °F
• PSA: 35.25000
• Density: 0.86
• LogP: 1.41190
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 105.060990509
• Heavy Atom Count: 6
• Complexity: 40.5

Purity/Quality:

99% ^*data from raw suppliers

O-(Trimethylsilyl)hydroxylamine >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)ON
• Uses: O-(Trimethylsilyl)hydroxylamine may be used for the preparation of O-trimethylsilyl oxime ethers.

Technology Process of O-(TRIMETHYLSILYL)HYDROXYLAMINE

There total 6 articles about O-(TRIMETHYLSILYL)HYDROXYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

trimethylsilyl N-[(chloromethyl)dimethylsilyl]-N-(trimethylsiloxy)carbamate → Hexamethyldisiloxane (107-46-0) + O-Trimethylsilylhydroxylamine (22737-36-6) + 1,3-Bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane (2362-10-9)

Guidance literature:

In water; acetone; at 60 ℃;

DOI:10.1023/B:RUGC.0000016017.44026.39

Reference yield: 80.0%

chloro-trimethyl-silane (75-77-4) → O-Trimethylsilylhydroxylamine (22737-36-6)

Guidance literature:

With hydroxylamine hydrochloride; In dichloromethane; ethylenediamine; for 24h;

Reference yield: 51.0%

→ O-Trimethylsilylhydroxylamine (22737-36-6)

Guidance literature:

upstream raw materials:

trimethylsilyl amine

1,1,1,3,3,3-hexamethyl-disilazane

chloro-trimethyl-silane

Downstream raw materials:

N-<1-methyl-1-<4-(benzyloxy)phenyl>ethyl>hydroxylamine

N-(dimethylphenylsilyl)-N'-(trimethylsiloxy)urea

N-Trityl-L-Methioninhydroxylamid

C₁₄H₂₃NOSi

Refernces

• 1、 Kirilin,Belova,Zhvakina,Chernyshev. "Reaction of chloro(chlorodimethyl)dimethylsilane with O-silylurethanes and nicotinic hydrazide in the presence of hexamethyldisilazane". . p. 1539 - 1542. Retrieved 2007/10/03.
• 2、 -. "Process for the preparation of isocyanates and their use for the preparation of polyisocyanates containing ester". . . Retrieved 2008/06/13.