H-D-Val-OtBu.HCl

Base Information

• Chemical Name: H-D-Val-OtBu.HCl
• CAS No.: 104944-18-5
• Molecular Formula: C₉H₁₉NO₂*ClH
• Molecular Weight: 209.716
• Hs Code.: 2922499990
• Mol file: 104944-18-5.mol

Synonyms:D-Valine,1,1-dimethylethyl ester, hydrochloride (9CI);D-Valine tert-butyl esterhydrochloride;

Chemical Property of H-D-Val-OtBu.HCl

Chemical Property:

• Melting Point: 144-146 °C
• PSA: 52.32000
• LogP: 2.81370
• Storage Temp.: Store at 0°C

Purity/Quality:

99% ^*data from raw suppliers

D-Valine tert-butyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Valine tert-butyl ester hydrochloride is a protected form of D-Valine (V094220). D-Valine (an isomer of the essential amino acid L-Valine [V094205])exhibited inhibitory effects on fibroblasts that contaminated mammalian kidney cultures, allowing for selective growth epithelial cells. D-Valine is also known for its presence in the structure of Actinomycin D, an antitumour drug. D-Valine is naturally synthesized by Streptomyces antibioticus.

Technology Process of H-D-Val-OtBu.HCl

There total 1 articles about H-D-Val-OtBu.HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

D-Val-OH (640-68-6,25609-85-2,7004-03-7,921-10-8) + isobutene (115-11-7,15220-85-6) → t-butyl D-valinate hydrochloride (13518-40-6,75898-43-0,104944-18-5)

Guidance literature:

With sulfuric acid; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)91366-3

Reference yield: 99.55%

4-chlorosulfonyl-benzoic acid methyl ester (69812-51-7) + t-butyl D-valinate hydrochloride (13518-40-6,75898-43-0,104944-18-5) → 4-(1-tert-butoxycarbonyl-2-methyl-propylsulfamoyl)-benzoic acid methyl ester

Guidance literature:

With pyridine; In acetonitrile; at 20 ℃; for 4h;

Reference yield: 94.0%

t-butyl D-valinate hydrochloride (13518-40-6,75898-43-0,104944-18-5) + 4-bromobenzenesulfonyl chloride (98-58-8) → (R)-2-(4-bromobenzenesulfonylamino)-3-methylbutyric acid tert-butyl ester (779341-90-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; Cooling with ether-dry ice;

upstream raw materials:

D-Val-OH

isobutene

Downstream raw materials:

Z-S-Pro-R-Val-OtBu

(R)-2-(4-bromobenzenesulfonylamino)-3-methylbutyric acid tert-butyl ester

2-(4-chloro-3-nitro-benzenesulfonylamino)-3-methyl-butyric acid tert-butyl ester

(R)-3-Methyl-2-[(Z)-(7S,8R,9S)-7,8,9-tris-benzyloxy-9-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-non-5-enoylamino]-butyric acid tert-butyl ester

Refernces