4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine

Base Information

• Chemical Name: 4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine
• CAS No.: 1313718-69-2
• Molecular Formula: C₁₅H₁₇N₅O₄
• Molecular Weight: 331.331
• Mol file: 1313718-69-2.mol

Synonyms:4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine

Chemical Property of 4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine

There total 3 articles about 4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.83%

4-amino-3-nitrophenylboronic acid pinacol ester (833486-94-5) + 4-(2-chloro-5-methoxy-pyrimidin-4-yl)-morpholine (1269626-37-0) → 4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine (1313718-69-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; Reflux;

Reference yield:

5-Methoxypyrimidine-2,4(1H,3H)-dione (6623-81-0) → 4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine (1313718-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate; N,N-dimethyl-aniline / Cooling with ice; Reflux

2: toluene / -10 - 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Reflux

With sodium carbonate; N,N-dimethyl-aniline; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; toluene;

Reference yield:

2,4-dichloro-5-methoxypyrimidine (19646-07-2) → 4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine (1313718-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / -10 - 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Reflux

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; toluene;

upstream raw materials:

2,4-dichloro-5-methoxypyrimidine

4-amino-3-nitrophenylboronic acid pinacol ester

4-(2-chloro-5-methoxy-pyrimidin-4-yl)-morpholine

5-Methoxypyrimidine-2,4(1H,3H)-dione

Downstream raw materials:

4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)benzene-1,2-diamine

Refernces