2,4-Dichloro-5-methoxypyrimidine

Base Information

• Chemical Name: 2,4-Dichloro-5-methoxypyrimidine
• CAS No.: 19646-07-2
• Molecular Formula: C5H4Cl2N2O
• Molecular Weight: 179.006
• Hs Code.: 29335990
• Mol file: 19646-07-2.mol

Synonyms:5-Methoxy-2,4-dichloropyrimidine pyrimidine;

Chemical Property of 2,4-Dichloro-5-methoxypyrimidine

Chemical Property:

• Appearance/Colour: white or slight yellow solid
• Vapor Pressure: 0.0204mmHg at 25°C
• Melting Point: 68 °C
• Refractive Index: 1.541
• Boiling Point: 259.9 °C at 760 mmHg
• PKA: -2.67±0.29(Predicted)
• Flash Point: 111 °C
• PSA: 35.01000
• Density: 1.446 g/cm³
• LogP: 1.79200
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dichloro-5-methoxypyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn,C
• Hazard Codes: Xi,C,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dichloro-5-methoxypyrimidine can be used for preparation of heteroarylpiperazine derivatives for use in treatment of Alzheimer's disease. It is used for preparation of heteroarylpiperazine derivatives for use in treatment of Alzheimer's disease.

Technology Process of 2,4-Dichloro-5-methoxypyrimidine

There total 3 articles about 2,4-Dichloro-5-methoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-Methoxypyrimidine-2,4(1H,3H)-dione (6623-81-0) → 2,4-dichloro-5-methoxypyrimidine (19646-07-2)

Guidance literature:

With pyridine; trichlorophosphate; at 180 ℃; under 150.015 - 900.09 Torr; Neat (no solvent); Large scale reaction;

DOI:10.1021/jo2003715

Reference yield: 64.0%

5-methoxyuracil (6623-81-0) → 2,4-dichloro-5-methoxypyrimidine (19646-07-2)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-aniline; for 20h; Reflux;

DOI:10.1021/jm100556b

Reference yield:

→ 2,4-dichloro-5-methoxypyrimidine (19646-07-2)

Guidance literature:

2.4-Dihydroxy-5-methoxy-pyrimidin in sd. POCl3, Dimethylanilin <3h>;

upstream raw materials:

5-methoxyuracil

5-Methoxypyrimidine-2,4(1H,3H)-dione

Downstream raw materials:

2-{[2-chloro-5-(methoxy)-4-pyrimidinyl]amino}benzamide

4-[5-methoxy-2-(3-nitrophenyl)pyrimidin-4-yl]morpholine

4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)-2-nitrophenylamine

4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)benzene-1,2-diamine

Refernces

• 1、 -. "Preparation method of 2-chloro-5-methoxypyrimidine". Paragraph 0018-0023. . Retrieved 2019/10/23.
• 2、 Sun, Zhihua,Wang, Han,Wen, Kun,Li, Ya,Fan, Erkang. "Solvent-free or low-solvent large-scale preparation of chloropyrimidine and analogues". experimental part. p. 4149 - 4153. Retrieved 2011/07/07.