2-Benzamidobenzamide

Base Information

• Chemical Name: 2-Benzamidobenzamide
• CAS No.: 18543-22-1
• Molecular Formula: C14H12N2O2
• Molecular Weight: 240.261
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID90351513
• Nikkaji Number: J1.743.656B
• Wikidata: Q82127979
• ChEMBL ID: CHEMBL3828757
• Mol file: 18543-22-1.mol

Synonyms:2-benzamidobenzamide;18543-22-1;2-(benzoylamino)benzamide;Benzamide,N-[2-(aminocarbonyl)phenyl]-;Benzamide, N-[2-(aminocarbonyl)phenyl]-;N-(2-Carbamoylphenyl)benzamide;CDS1_004026;CBMicro_017530;N-[2-(AMINOCARBONYL)PHENYL] BENZAMIDE;Oprea1_141379;Oprea1_410205;DivK1c_005066;SCHEMBL786246;CHEMBL3828757;DTXSID90351513;HMS1667A21;2-[(phenylcarbonyl)amino]benzamide;CCG-6034;MFCD00495221;STK016688;AKOS000483649;AC-20345;BIM-0017377.P001;CS-0306424;Z57196971

Chemical Property of 2-Benzamidobenzamide

Chemical Property:

• Vapor Pressure: 3.71E-05mmHg at 25°C
• Refractive Index: 1.668
• Boiling Point: 353 °C at 760 mmHg
• Flash Point: 167.3 °C
• PSA: 72.19000
• Density: 1.284 g/cm³
• LogP: 2.81110
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 240.089877630
• Heavy Atom Count: 18
• Complexity: 311

Purity/Quality:

98%Min ^*data from raw suppliers

BENZAIMDE,N-[2-(AMINOCARBONYL)PHENYL]- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2C(=O)N

Technology Process of 2-Benzamidobenzamide

There total 22 articles about 2-Benzamidobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzoyl chloride (98-88-4) + anthranilic acid amide (28144-70-9,88-68-6) → 2-benzoylaminobenzamide (18543-22-1)

Guidance literature:

With pyridine; In tetrahydrofuran; for 16h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.04.041

Reference yield: 99.0%

2-phenyl-4H-3,1-benzoxazin-4-one (1022-46-4) → 2-benzoylaminobenzamide (18543-22-1)

Guidance literature:

With ammonium hydroxide; oxygen; copper(I) bromide; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 24h;

DOI:10.1016/j.tet.2016.05.054

Reference yield: 85.0%

anthranilic acid amide (28144-70-9,88-68-6) + benzoic acid (65-85-0,8013-63-6) → 2-benzoylaminobenzamide (18543-22-1)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/j.bmcl.2005.02.084

upstream raw materials:

N-(2-cyanophenyl)benzamide

benzoyl chloride

anthranilic acid amide

anthranilic acid nitrile

Downstream raw materials:

2-phenyl-4-hydroxy quinazoline

2-(2-hydroxyphenyl)quinazolin-4(1H)-one

benzyl(2-phenylquinazolin-4-yl)amine

N⁴,N⁴-diethyl-1-methyl-N¹-(2-phenyl-quinazolin-4-yl)-butanediyldiamine

Refernces

• 1、 Neerathilingam, Nalladhambi,Bhargava Reddy, Mandapati,Anandhan, Ramasamy. "Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N, N-Dibenzylanilines". . p. 15117 - 15127. Retrieved 2021/10/25.
• 2、 Wu, Hongfeng,An, Qi,He, Chaoyin,Fan, Xiaodong,Guo, Weihao,Zuo, Minghui,Xu, Chunzhao,Guo, Rui,Chu, Wenyi,Sun, Zhizhong. "Synthesis of 2-(2-Hydroxyaryl)-4H-benzo[e][1,3]oxazin-4-ones by Palladium-Catalyzed C(sp2)?H Hydroxylation via Electro-chemical Oxidation". supporting information. p. 2459 - 2465. Retrieved 2020/04/29.