4-BENZYLPHENYLACETONITRILE

Base Information

• Chemical Name: 4-BENZYLPHENYLACETONITRILE
• CAS No.: 101096-72-4
• Molecular Formula: C15H13N
• Molecular Weight: 207.275
• Hs Code.: 2926909090
• Mol file: 101096-72-4.mol

Synonyms:Acetonitrile,(a-phenyl-p-tolyl)- (6CI);(4-Benzylphenyl)acetonitrile;4-Benzylbenzyl cyanide;

Chemical Property of 4-BENZYLPHENYLACETONITRILE

Chemical Property:

• Vapor Pressure: 2.98E-05mmHg at 25°C
• Melting Point: 34-36 °C
• Refractive Index: 1.581
• Boiling Point: 356.1 °C at 760 mmHg
• Flash Point: 183.2 °C
• PSA: 23.79000
• Density: 1.062 g/cm³
• LogP: 3.34348

Purity/Quality:

98%min ^*data from raw suppliers

4-Benzylphenylacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R22:Harmful if swallowed.
• Hazard Codes: R22:Harmful if swallowed.
• Statements: 22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BENZYLPHENYLACETONITRILE

There total 5 articles about 4-BENZYLPHENYLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

sodium cyanide (773837-37-9) + 4-benzylbenzyl chloride (14297-39-3) → 4-benzyl-1-cyanomethylbenzene (101096-72-4)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 80 ℃; for 24h;

DOI:10.1039/c8ra07841f

Reference yield:

4-benzylbenzyl chloride (14297-39-3) → 4-benzyl-1-cyanomethylbenzene (101096-72-4)

Guidance literature:

In sodium bicarbonate; dimethylchloride (DMF); ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

1-(bromomethyl)-4-(phenylmethyl)-benzene (54588-96-4) + sodium cyanide (143-33-9,25596-52-5) + 3-benzyl-1-bromomethylbenzene (69410-45-3) → 3-benzyl-1-cyanomethylbenzene (208042-69-7) + 4-benzyl-1-cyanomethylbenzene (101096-72-4)

Guidance literature:

upstream raw materials:

4-benzylbenzyl chloride

sodium cyanide

1-(bromomethyl)-4-(phenylmethyl)-benzene

3-benzyl-1-bromomethylbenzene

Downstream raw materials:

4-benzylphenylacetamide

(4-benzyl-phenyl)-acetic acid ethyl ester

[4-(4-{4-[4-(4-Ethoxycarbonylmethyl-benzyl)-benzoyl]-benzoyl}-benzyl)-phenyl]-acetic acid ethyl ester

[4-(4-{4-[4-(4-Ethoxycarbonylmethyl-benzyl)-benzyl]-benzyl}-benzyl)-phenyl]-acetic acid ethyl ester

Refernces

• 1、 -. "Phenyl acetamides as sPLA2 inhibitors". Page column 15. . Retrieved 2008/06/13.