cyclohexyl methyl ketone oxime

Base Information

• Chemical Name: cyclohexyl methyl ketone oxime
• CAS No.: 52316-19-5
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.213
• Mol file: 52316-19-5.mol

Synonyms:cyclohexyl methyl ketone oxime

Chemical Property of cyclohexyl methyl ketone oxime

Chemical Property:

Purity/Quality:

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Technology Process of cyclohexyl methyl ketone oxime

There total 6 articles about cyclohexyl methyl ketone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Cyclohexyl methyl ketone (823-76-7) → cyclohexyl methyl ketone oxime (52316-19-5)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; Reflux;

DOI:10.1021/jacs.8b01618

Reference yield: 72.0%

2-cyclohexylacetylene (931-48-6) → cyclohexyl methyl ketone oxime (52316-19-5)

Guidance literature:

With hydroxylamine; In water; isopropyl alcohol; at 140 ℃; for 4h; regioselective reaction; Inert atmosphere; Microwave irradiation;

DOI:10.1021/ja806300r

Reference yield: 66.0%

N-methylcyclohexanecarboxamide (6830-84-8) → cyclohexyl methyl ketone oxime (52316-19-5)

Guidance literature:

With hydrogenchloride; acetic acid; In water; at 75 ℃; for 10h;

DOI:10.1134/S1070428011110170

upstream raw materials:

Cyclohexyl methyl ketone

2-cyclohexylacetylene

N-methylcyclohexanecarboxamide

Acetaldehyde oxime

Downstream raw materials:

N-cyclohexylacetamide

[(1S)-1-cyclohexylethyl]amine

[(1R)-1-cyclohexylethyl]amine

1-cyclohexyl-N-(diphenylphosphinyl)ethanimine

Refernces

• 1、 -. "ENAMIDE PROCESS". Paragraph 0207; 0208. . Retrieved 2018/08/20.
• 2、 -. "ANTIVIRAL OXIME PHOSPHORAMIDE COMPOUNDS". Page/Page column 28; 29. . Retrieved 2017/07/06.