3-CHLOROPHENYLGLYOXAL HYDRATE

Base Information

• Chemical Name: 3-CHLOROPHENYLGLYOXAL HYDRATE
• CAS No.: 177288-16-3
• Molecular Formula: C8H7ClO3
• Molecular Weight: 186.595
• Hs Code.: 2915900090
• Mol file: 177288-16-3.mol

Synonyms:(3-chlorophenyl)(oxo)acetaldehyde hydrate;benzeneacetaldehyde, 3-chloro-α-oxo-, hydrate (1:1);(3-Chlorophenyl)(oxo)acetaldehyde hydrate (1:1);

Chemical Property of 3-CHLOROPHENYLGLYOXAL HYDRATE

Chemical Property:

• Vapor Pressure: 2.74E-05mmHg at 25°C
• Boiling Point: 343.2 °C at 760 mmHg
• Flash Point: 161.4 °C
• PSA: 57.53000
• LogP: 0.83340

Purity/Quality:

99% ^*data from raw suppliers

3-ChlorophenylglyoxalHydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLOROPHENYLGLYOXAL HYDRATE

There total 2 articles about 3-CHLOROPHENYLGLYOXAL HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-Chloroacetophenone (99-02-5) → C8H7ClO3 (177288-16-3)

Guidance literature:

With selenium(IV) oxide; water; In 1,4-dioxane; at 50 - 55 ℃; Reflux; Inert atmosphere; Schlenk technique;

DOI:10.1021/ja409859x

Reference yield:

3-chlorophenylglyoxal (27700-54-5) → C8H7ClO3 (177288-16-3)

Guidance literature:

With water; for 0.0833333h; Reflux;

DOI:10.1021/acs.joc.6b01040

Reference yield: 97.0%

2,4-dimethyl-3-pentanol (600-36-2) + C8H7ClO3 (177288-16-3) → C15H21ClO3

Guidance literature:

With C₂₃H₃₉N₃O₃; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 3h; enantioselective reaction; Inert atmosphere; Molecular sieve; Schlenk technique;

DOI:10.1021/ja409859x

upstream raw materials:

3'-Chloroacetophenone

3-chlorophenylglyoxal

Downstream raw materials:

(E)-1-(3-chlorophenyl)-2-((4-methoxyphenyl)imino)ethanone

(R)-2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline

N-[2-(3-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-4-methylbenzenesulfonamide

(S)-tert-butyl α-hydroxy-α-(3-chlorophenyl)acetate

Refernces

• 1、 Wang, Qiang,Xu, Youwei,Yang, Xifa,Li, Yunyun,Li, Xingwei. "Naphthol synthesis: Annulation of nitrones with alkynes: Via rhodium(III)-catalyzed C-H activation". supporting information. p. 9640 - 9643. Retrieved 2017/09/01.
• 2、 Lu, Xin-Mou,Cai, Zhong-Jian,Li, Jian,Wang, Shun-Yi,Ji, Shun-Jun. "Synthesis of 7-hydroxy-6,7-dihydro-indole and 6′,7′-dihydro-3,7′-biindole derivatives from domino reactions of arylglyoxals or methyl ketones with enamines". . p. 51501 - 51507. Retrieved 2015/06/25.