Technology Process of 4-(2-Chloro-phenyl)-2-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene
There total 6 articles about 4-(2-Chloro-phenyl)-2-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol;
for 5h;
under 760 Torr;
DOI:10.1021/jm00108a031
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 39 percent / Ph3P, CuI, Et3N, palladium acetate / dimethylformamide / 5 h
2: 44 percent / H2 / 5percent Pd/C / ethanol; tetrahydrofuran / 5 h / 760 Torr
With
copper(l) iodide; hydrogen; palladium diacetate; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a031
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / ICl / acetic acid / 0.25 h / Ambient temperature
2: Ph3P, CuI, Et3N, palladium acetate / acetonitrile / 2 h / Ambient temperature
3: K2CO3 / methanol / 2 h / Ambient temperature
4: 39 percent / Ph3P, CuI, Et3N, palladium acetate / dimethylformamide / 5 h
5: 44 percent / H2 / 5percent Pd/C / ethanol; tetrahydrofuran / 5 h / 760 Torr
With
copper(l) iodide; hydrogen; palladium diacetate; Iodine monochloride; potassium carbonate; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00108a031