2,4-DIFLUOROBENZONITRILE

Base Information

• Chemical Name: 2,4-DIFLUOROBENZONITRILE
• CAS No.: 103496-86-2
• Molecular Formula: C₇H₃F₂N
• Molecular Weight: 139.104
• Mol file: 103496-86-2.mol

Synonyms:2,4-Difluorobenzonitrileanion radical

Chemical Property of 2,4-DIFLUOROBENZONITRILE

Chemical Property:

• Vapor Pressure: 0.845mmHg at 25°C
• Melting Point: 45-50℃
• Refractive Index: 1.486
• Boiling Point: 181.6°Cat760mmHg
• Flash Point: 63.6°C
• PSA: 23.79000
• Density: 1.26g/cm³
• LogP: 1.83648

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): R20/21/22:; R36/37/38:
• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:; R36/37/38:
• Safety Statements: S26:; S36/37/39:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIFLUOROBENZONITRILE

There total 16 articles about 2,4-DIFLUOROBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,4-difluorobenzamide (85118-02-1) → 2,4-difluorobenzonitrile (3939-09-1,103496-86-2)

Guidance literature:

With trifluoroacetic anhydride; In tetrahydrofuran; at 40 ℃; for 3h; Time; Temperature;

Reference yield: 85.6%

N-(2,4-difluorophenyl)formamide → 2,4-difluorobenzonitrile (3939-09-1,103496-86-2)

Guidance literature:

With triethylamine; trichlorophosphate; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

DOI:10.1002/ardp.201600307

Reference yield: 77.0%

sodium cyanide (773837-37-9) + 2,4-difluoro-1-iodobenzene (2265-93-2) → 2,4-difluorobenzonitrile (3939-09-1,103496-86-2)

Guidance literature:

With C₁₈H₁₄CuIN₄; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere; Sealed tube; UV-irradiation;

DOI:10.1002/adsc.201700213

upstream raw materials:

4-nitro-2-chlorobenzonitrile

2,4-dinitrobenzonitrile

1-chloro-2,4-difluorobenzene

potassium cyanide

Downstream raw materials:

6-fluoro-3-amino-1,2-benzisoxazole

4-(4-Cyano-3-fluoro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

2-fluoro-4-(methylsulfanyl)benzonitrile

4-fluoro-2-(methylthio)benzonitrile

Refernces

• 1、 Boechat, Nubia,Clark, James H.. "Fluorodenitrations using Tetramethylammonium Fluoride". . p. 921 - 922. Retrieved 1993.
• 2、 Cornella, Josep,Katzenburg, Felix,Leutzsch, Markus,N?thling, Nils,Pang, Yue. "Catalytic Hydrodefluorination via Oxidative Addition, Ligand Metathesis, and Reductive Elimination at Bi(I)/Bi(III) Centers". supporting information. p. 12487 - 12493. Retrieved 2021/08/30.
• 3、 -. "A process for preparing 2, 4 - difluoro phenyl nitrile (by machine translation)". . . Retrieved 2019/01/08.