7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine

Base Information

• Chemical Name: 7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine
• CAS No.: 819793-73-2
• Molecular Formula: C₁₆H₁₃ClN₄O
• Molecular Weight: 312.758
• Mol file: 819793-73-2.mol

Synonyms:7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine

Chemical Property of 7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine

There total 2 articles about 7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione (4547-02-8) → 7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine (819793-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile; H₂O / 3 h / 20 °C

2: 0.55 g / sodium nitrite; AcOH / 3 h / 20 °C

With acetic acid; sodium nitrite; In water; acetonitrile;

DOI:10.1055/s-2004-831243

Reference yield:

desmethyldiazepam (1088-11-5) → 7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine (819793-73-2)

Guidance literature:

Multi-step reaction with 3 steps

1: P₂S₅; NaHCO₃ / acetonitrile / 24 h / Heating

2: acetonitrile; H₂O / 3 h / 20 °C

3: 0.55 g / sodium nitrite; AcOH / 3 h / 20 °C

With tetraphosphorus decasulfide; sodium hydrogencarbonate; acetic acid; sodium nitrite; In water; acetonitrile;

DOI:10.1055/s-2004-831243

Reference yield: 87.0%

acetic acid hydrazide (1068-57-1) + 7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine (819793-73-2) → alprazolam (28981-97-7)

Guidance literature:

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 120 ℃; for 1h;

DOI:10.3390/11080583

upstream raw materials:

desmethyldiazepam

7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione

Downstream raw materials:

8?chloro?6?phenyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

alprazolam

8-chloro-1-methyl-6-phenyl-4H-imidazo[1,2-a]-[1,4]benzodiazepine

(1,2-a)4H-imidazo (1,4)benzodiazepine 4 oxide

Refernces