2-bromo-1,1,2,2-tetrafluoroethylbenzene

Base Information

• Chemical Name: 2-bromo-1,1,2,2-tetrafluoroethylbenzene
• CAS No.: 772339-81-8
• Molecular Formula: C₈H₅BrF₄
• Molecular Weight: 257.025
• Mol file: 772339-81-8.mol

Synonyms:2-bromo-1,1,2,2-tetrafluoroethylbenzene

Chemical Property of 2-bromo-1,1,2,2-tetrafluoroethylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-1,1,2,2-tetrafluoroethylbenzene

There total 2 articles about 2-bromo-1,1,2,2-tetrafluoroethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

α-bromo-α,α-difluoro-acetophenone (1610-04-4) → 2-bromo-1,1,2,2-tetrafluoroethylbenzene (772339-81-8)

Guidance literature:

With diethylamino-sulfur trifluoride; In chloroform; for 34h; Heating;

DOI:10.1016/j.jfluchem.2003.11.031

Reference yield:

2,2-difluoro-1-phenyl-1-trimethylsiloxyethene (86340-78-5) → 2-bromo-1,1,2,2-tetrafluoroethylbenzene (772339-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 20.03 g / Br₂ / CH₂Cl₂ / 0.5 h / -78 °C

2: 58 percent / diethylaminosulfur trifluoride / CHCl₃ / 34 h / Heating

With diethylamino-sulfur trifluoride; bromine; In dichloromethane; chloroform;

DOI:10.1016/j.jfluchem.2003.11.031

Reference yield: 94.0%

chloro-trimethyl-silane (75-77-4) + 2-bromo-1,1,2,2-tetrafluoroethylbenzene (772339-81-8) → C11H14F4Si

Guidance literature:

With TurboGrignard; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1021/acs.organomet.7b00892

upstream raw materials:

α-bromo-α,α-difluoro-acetophenone

2,2-difluoro-1-phenyl-1-trimethylsiloxyethene

Downstream raw materials:

1,1,2,2-tetrafluoro-1,2-diphenylethane

Refernces

• 1、 Zhu, Jieming,Ni, Chuanfa,Gao, Bing,Hu, Jinbo. "Copper(0)-mediated fluoroalkylation of iodobenzene with 2-bromo-1,1,2,2-tetrafluoroethyl compounds: Investigation on the influence of R substituent on the reactivity of RCF2Cu species". . p. 139 - 147. Retrieved 2015/03/04.