2-CHLOROPHENYL METHYL SULFONE

Base Information

• Chemical Name: 2-CHLOROPHENYL METHYL SULFONE
• CAS No.: 17482-05-2
• Molecular Formula: C7H7ClO2S
• Molecular Weight: 190.65
• Hs Code.: 2930909899
• Mol file: 17482-05-2.mol

Synonyms:Sulfone,o-chlorophenyl methyl (7CI,8CI);2-Chlorophenyl methyl sulfone;o-Chlorophenylmethyl sulfone;

Chemical Property of 2-CHLOROPHENYL METHYL SULFONE

Chemical Property:

• Vapor Pressure: 0.000171mmHg at 25°C
• Melting Point: 90-94 °C
• Refractive Index: 1.541
• Boiling Point: 340.3 °C at 760 mmHg
• Flash Point: 159.6 °C
• Density: 1.331 g/cm³
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-ChlorophenylMethylSulphone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-36/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLOROPHENYL METHYL SULFONE

There total 20 articles about 2-CHLOROPHENYL METHYL SULFONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chlorothioanisole (17733-22-1) → o-chlorophenyl methyl sulfone (17482-05-2)

Guidance literature:

With sodium tungstate (VI) dihydrate; dihydrogen peroxide; In methanol; water; at 40 ℃;

DOI:10.1039/b912521n

Reference yield: 87.0%

di-tert-butyl peroxide (110-05-4) + 2-chlorobenzenesulfinic acid sodium salt (15946-36-8) → o-chlorophenyl methyl sulfone (17482-05-2)

Guidance literature:

With water; at 110 ℃; for 12h; Sealed tube; Green chemistry;

DOI:10.1016/j.tetlet.2017.12.074

Reference yield: 85.0%

N-amino-o-chlorobenzenesulfonamide (5906-98-9) + Dimethyl phosphite (868-85-9) → o-chlorophenyl methyl sulfone (17482-05-2)

Guidance literature:

With sodium iodide; In 1,2-dimethoxyethane; water; at 65 ℃;

DOI:10.1055/a-1581-2271

upstream raw materials:

2-chlorothioanisole

methyl fluorosulfonate

chlorobenzene

Methanesulfonic anhydride

Downstream raw materials:

1-methanesulfonyl-2-methoxy-benzene

o-Ethoxy-phenylmethylsulfon

o-methylsulphonylphenyl methyl sulphide

1,2-bis(methanesulfonyl)benzene

Refernces

• 1、 Liu, Teng,Yu, Shiwen,Shen, Xiang,Li, Yixian,Liu, Jianjun,Huang, Chao,Cheng, Feixiang. "High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite". . p. 153 - 160. Retrieved 2021/10/04.
• 2、 Cheng, Zhen,Sun, Pengchao,Tang, Ailing,Jin, Weiwei,Liu, Chenjiang. "Switchable Synthesis of Aryl Sulfones and Sulfoxides through Solvent-Promoted Oxidation of Sulfides with O2/Air". supporting information. p. 8925 - 8929. Retrieved 2019/11/14.