rac-N-(2-phenylpropyl)formamide

Base Information

• Chemical Name: rac-N-(2-phenylpropyl)formamide
• CAS No.: 85070-52-6
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Mol file: 85070-52-6.mol

Synonyms:rac-N-(2-phenylpropyl)formamide

Chemical Property of rac-N-(2-phenylpropyl)formamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-N-(2-phenylpropyl)formamide

There total 2 articles about rac-N-(2-phenylpropyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-phenylpropylamine (582-22-9) + formic acid ethyl ester (109-94-4) → rac-N-(2-phenylpropyl)formamide (85070-52-6)

Guidance literature:

With Novozyme 435 CALB; In tetrahydrofuran; at 20 ℃; Green chemistry; Enzymatic reaction;

DOI:10.1039/c6cc07679c

Reference yield:

2-phenylpropylamine (582-22-9) + formic acid (64-18-6) → rac-N-(2-phenylpropyl)formamide (85070-52-6)

Guidance literature:

at 170 ℃;

Reference yield:

rac-N-(2-phenylpropyl)formamide (85070-52-6) → 4-methylisoquinoline (1196-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus (V)-oxide; tetralin

2: palladium / 190 °C

With tetralin; phosphorus pentoxide; palladium;

upstream raw materials:

2-phenylpropylamine

formic acid

formic acid ethyl ester

Downstream raw materials:

4-methylisoquinoline

Refernces

• 1、 Caroon, Joan M.,Clark, Robin D.,Kluge, Arthur F.,Lee, Chi-Ho,Strosberg, Arthur M.. "Synthesis and Antihypertensive Activity of a Series of Spiroquinolizine-2,5'-oxazolidin-2'-one>s". . p. 1426 - 1433. Retrieved 2007/10/02.