3-METHYL-4-PHENYLPYRIDINE

Base Information

• Chemical Name: 3-METHYL-4-PHENYLPYRIDINE
• CAS No.: 2052-92-8
• Molecular Formula: C12H11N
• Molecular Weight: 169.226
• Hs Code.: 2933399090
• Mol file: 2052-92-8.mol

Synonyms:3-Picoline,4-phenyl- (7CI,8CI);3-Methyl-4-phenylpyridine;

Chemical Property of 3-METHYL-4-PHENYLPYRIDINE

Chemical Property:

• Vapor Pressure: 0.0133mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 267.6 °C at 760 mmHg
• Flash Point: 109 °C
• PSA: 12.89000
• Density: 1.03 g/cm³
• LogP: 3.05700

Purity/Quality:

99% ^*data from raw suppliers

3-METHYL-4-PHENYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-4-PHENYLPYRIDINE

There total 20 articles about 3-METHYL-4-PHENYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-Methyl-4-phenyl-4H-pyridine-1-carboxylic acid ethyl ester (132819-56-8) → 3-methyl-4-phenyl-pyridine (2052-92-8) + ethyl methyl carbonate (623-53-0,872521-98-7)

Guidance literature:

With sodium methylate; In methanol; at 18 ℃; anodic oxidation (graphite-rod electrodes), 6 F/mol passed through the solution;

Reference yield: 89.0%

(E)-3-phenylpropenal (14371-10-9) + Propargylamine (2450-71-7) → 3-methyl-4-phenyl-pyridine (2052-92-8)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 80 ℃; for 15h; Inert atmosphere; Molecular sieve;

DOI:10.1039/c9cc01097a

Reference yield: 89.0%

4-phenyl-3-pyridinecarbaldehyde (46268-56-8) → 3-methyl-4-phenyl-pyridine (2052-92-8)

Guidance literature:

With potassium hydroxide; hydrazine; In ethylene glycol; Heating;

upstream raw materials:

1,3-dimethyl-4-phenyl-1,2,5,6-tetrahydropyridine

3-Methylpyridine

benzoyl chloride

4-phenyl-3-pyridinecarbaldehyde

Downstream raw materials:

3-methyl-4-(4-nitrophenyl)pyridine

1,3-dimethyl-4-phenylpyridinium iodide

1,3-dimethyl-4-phenyl-1,2,5,6-tetrahydropyridine

1,5-dimethyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide

Refernces

• 1、 Zhao, Zhiwen,Wei, Hongbo,Xiao, Ke,Cheng, Bin,Zhai, Hongbin,Li, Yun. "Facile Synthesis of Pyridines from Propargyl Amines: Concise Total Synthesis of Suaveoline Alkaloids". supporting information. p. 1148 - 1152. Retrieved 2019/01/04.
• 2、 Uredi, Dilipkumar,Motati, Damoder Reddy,Blake Watkins. "A simple, tandem approach to the construction of pyridine derivatives under metal-free conditions: A one-step synthesis of the monoterpene natural product, (-)-actinidine". supporting information. p. 3270 - 3273. Retrieved 2019/03/30.